Chemoradiation therapy used on pediatric oncology patients often causes dental developmental anomalies that affect future dental care. Defects noted include tooth and root agenesis, root thinning and shortening, and localized enamel defects. Histologically, these defects appear as osteoid-like niches in the developing dentin which alter the overlying enamel. Odontogenic cell sensitivity is depe...

Several morphological anomalies of teeth have been reported along with associated problems of eruption, alignment and susceptibility to dental caries. 1-3 Possible chronological effects of tooth development associated with position on the dental lamina have not been discussed. This paper reports two cases each with maxillary molars developing chronologically midway between the times anticipated...

The question of phenotypic convergence across a signalling pathway has important implications for both developmental and evolutionary biology. The ERK-MAPK cascade is known to play a central role in dental development, but the relative roles of its components remain unknown. Here we investigate the diversity of dental phenotypes in Spry2(-/-), Spry4(-/-), and Rsk2(-/Y) mice, including the incid...

PURPOSE The purpose of this study was to determine whether the orthodontic treatment provided by pediatric dentists reflects the orthodontic training received in pediatric dental residency programs. METHODS Five questions from a survey of the American Academy of Pediatric Dentistry (AAPD) diplomates in August 2002 and a survey of pediatric dental residency program directors in June 2002 were ...

Congenitally missing teeth, or hypodontia, is one of the most common abnormalities of the human dentition and has a critical and often lifelong impact on the oral health of affected individuals. Here we review hypodontia and describe the patterns of inheritance it can display. A short review of tooth development and a primer in human genetics are presented. Approaches used to determine the unde...

STATEMENT OF THE PROBLEM The prevalence of overweight and obesity has been increasing markedly in recent years. It may influence growth in pre pubertal children. PURPOSE The purpose of this study was to determine whether increased Body Mass Index (BMI) is associated with accelerated skeletal maturation and dental maturation in six to fifteen years old orthodontic patients in Shiraz, Iran. M...

Teeth develop as ectodermal appendages in vertebrate embryos, and their early development resembles morphologically as well as molecularly other organs such as hairs and glands. Interactions between the ectoderm and underlying mesenchyme constitute a central mechanism regulating the morphogenesis of all these organs. Tooth morphogenesis is an advancing process that is regulated by sequential an...

Humans' prolonged somatic development and life history are unique among primates, yet their evolutionary origins remain unclear. Dental development has been used as a proxy to reconstruct life history evolution in the hominin clade and indicates a recent emergence of the human developmental pattern. Here, we analyse tooth formation and eruption in two developing dentitions of Homo naledi, a lat...

The formation of mammalian dentition is one of the most remarkable processes in development and provides a powerful model for studying the epithelialmesenchymal interactions that control patterning and morphogenesis of variety of developmental processes. The tooth development involves a complex series of genetic interactions involving growth factors, transcription factors, signal receptors and ...

Chorion type may significantly influence the prenatal environment of twins. This study explored the associations between chorion type and gestational age, birth weight, birth length, and the timing of emergence of the first primary tooth in two populations of twins, Australian and Dutch. Additionally, we investigated the relationship between chorion type and birth weight discordance (BWD) in or...