CONTEXT Sleep abnormalities, including obstructive sleep apnea (OSA), have been associated with insulin resistance. OBJECTIVE To determine the relationship between sleep, including OSA, and glucose parameters in a prospectively assembled cohort of chronically sleep-deprived obese subjects. DESIGN Cross-sectional evaluation of a prospective cohort study. SETTING Tertiary Referral Research ...

Obstructive sleep apnea (OSA) occurs in 2% of middle-aged women and 4% of middle-aged men with a higher prevalence among obese subjects. This condition is considered as an independent risk factor for cerebrovascular and cardiovascular diseases. One of the major pathophysiological characteristics of OSA is intermittent hypoxia. Hypoxia can lead to oxidative stress and overproduction of reactive ...

OBJECT Obstructive sleep apnea (OSA) is a commonly encountered impairment in both clinical and insurance medicine. Surprisingly, relatively few data exist regarding the mortality or morbidity of sleep apnea. This paper reviews the mortality and morbidity implications of this disorder. METHODS Literature review using Medline. RESULTS AND CONCLUSIONS Much of the morbidity and mortality attrib...

A 25-year-old woman, gravida 4 para 2, at 37 weeks gestation was evaluated and treated for preeclampsia. Overnight, the patient had a witnessed apneic episode with maternal oxygen desaturation and concurrent fetal heart rate deceleration. She subsequently delivered an infant that was small for gestational age. This is the first case described with confirmed obstructive sleep apnea by formal pol...

These practice parameters are an update of the previously published recommendations regarding the use of autotitrating positive airway pressure (APAP) devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome. Continuous positive airway pressure (CPAP) at an effective setting verified by attended polysomnography is a standard treatment for obstructive sle...

In a recent issue of CHEST (June 2002) Valipour and coworkers1 reported that symptomatic gastroesophageal reflux (GER) is common in subjects with a breathing sleep disorder, but that there was no difference between those with obstructive sleep apnea (OSA) and subjects who snore. We agree with the authors that GER is common in subjects with a breathing sleep disorder. However, we do not agree wi...

In a recent issue of CHEST (June 2002) Valipour and coworkers1 reported that symptomatic gastroesophageal reflux (GER) is common in subjects with a breathing sleep disorder, but that there was no difference between those with obstructive sleep apnea (OSA) and subjects who snore. We agree with the authors that GER is common in subjects with a breathing sleep disorder. However, we do not agree wi...

Obstructive sleep apnea (OSA) is a common type of sleep apnea and is caused by obstruction of upper airway. Sleep apnea is clinically defined as frequent episodes of apnea, hypopnea and symptoms of functional impairment, which could be life-threatening and associated with extreme daytime hyper somnolence, dysfunction, discrements in health-related quality of life, automobile accidents, and card...

Obstructive sleep apnea (OSA) has been associated with many of the known risk factors for stroke including hypertension, diabetes and atrial fibrillation. There is also a large body of literature that suggests that OSA and stroke are independently associated. In this review, we will discuss the literature supporting OSA not only a risk factor for stroke, but also show how untreated OSA has been...