in traditional portfolio selection model coefficients often are certain and deterministic, but in real world these coefficients are probabilistic. so decision maker cannot estimate them exactly. financial optimization is one of the most attractive areas in decision under uncertainty. in the portfolio selection problem the decision maker considers simultaneously conflicting objectives such as ra...

Abstract: In this work, a nonsmooth multiobjective optimization problem involving generalized invexity with cone constraints and Applications (for short, (MOP)) is considered. The Kuhn-Tucker necessary and sufficient conditions for (MOP) are established by using a generalized alternative theorem of Craven and Yang. The relationship between weakly efficient solutions of (MOP) and vector valued s...

The convexity theory plays an important role in many aspects of mathematical programming. In recent years, in order to relax convexity assumption, various generalized convexity notions have been obtained. One of them is the concept of ) , ( r p B− invexity defined by T.Antczak [1], which extended the class of B − invex functions with respect toη and b and the classes of ) , ( r p invex function...

Background and purpose - Large metal-on-metal (MoM) articulations are associated with metal wear and corrosion, leading to increased metal ion concentrations and unacceptable revision rates. There are few comparative studies of 28-mm MoM articulations with conventional metal-on-polyethylene (MoP) couplings. We present a long-term follow-up of a randomized controlled trial comparing MoM versus M...

Extracorporeal photopheresis (ECP) is an important second-line therapy for graft-versus-host disease. A central therapeutic mechanism is the induction of immune tolerance through apoptosis in patient's leukocytes, caused by ex vivo incubation with 8-methoxypsoralen (8-MOP) and subsequent UVA irradiation. We hypothesized that different 8-MOP incubation times and an additional 8-MOP removal step ...

Opioid receptors are currently classified as mu (mu: mOP), delta (delta: dOP), kappa (kappa: kOP) with a fourth related non-classical opioid receptor for nociceptin/orphainin FQ, NOP. Morphine is the current gold standard analgesic acting at MOP receptors but produces a range of variably troublesome side-effects, in particular tolerance. There is now good laboratory evidence to suggest that blo...