نتایج جستجو برای: ob rb
تعداد نتایج: 21192 فیلتر نتایج به سال:
Hepatic VLDL production in ob/ob mice is not stimulated by massive de novo lipogenesis and is less sensitive to the suppressive effects of insulin Less suppression of VLDL production by insulin in ob/ob mice 66 ABSTRACT Type 2 diabetes mellitus in humans is associated with increased de novo lipogenesis (DNL), increased fatty acid (FA)-flux from peripheral tissues, decreased FA oxidation and hep...
Glucocorticoids have been implicated as pathophysiological mediators of obesity and insulin resistance and are regulated by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). This enzyme regenerates active corticosterone from inactive 11-keto forms. To assess the role of 11beta-HSD1-mediated synthesis of active corticosterone in leptin-related obesity and diabetes, we examined the periph...
introduction: multiple sclerosis (ms) is a chronic inflammatory demyelinating disease. in the present study, we investigated the response of subventricular zone (svz) adult stem cells in the experimental autoimmune encephalomyelitis (eae), an animal model of ms, and also the differentiation fate of these stem cells. methods: mice were immunized with mog peptide emulsified in complete freund&apo...
در این تحقیق قدرت بیمارگری سه ویروس Spodoptera littoralis NPV، Helicoverpa armigera NPV و Spodoptera litura NPV در سه غلظت مختلف 10۲×6، 104×6 و ۱۰۶×۶ OB در میلی‌لیتر روی لاروهای ۵ روزه کرم برگخوار مصری پنبه (Spodoptera littoralis) در دمای ۲5 درجه سلسیوس روی غذای مصنوعی بررسی شد. بیشترین طول دوره لاروی با 19.7 روز مربوط به ویروس H. armigera در غلظت ۱۰۴×6 OB در میلی‌لیتر بود که با بقیه تیمارها اخ...
The heart of leptin-deficient ob/ob mice is characterized by pathologic left ventricular hypertrophy along with elevated triglyceride (TG) content, increased stearoyl-CoA desaturase (SCD) activity, and increased myocyte apoptosis. In the present study, using an ob/ob;SCD1(-/-) mouse model, we tested the hypothesis that lack of SCD1 could improve steatosis and left ventricle (LV) function in lep...
BACKGROUND Intestinal dysfunction in the ob/ob mouse model of diabetes mimics that seen clinically. METHODS We determined the effects of a 4-week genistein diet (600 mg genistein/kg food) on intestinal function (contractility, morphology, AChR, and motility) in female ob/ob and lean mice. RESULTS Contractility of the jejunum in response to incrementally increasing concentrations of KCl was ...
It is important for our understanding of the pancreatic islets to study whether new islets are able to form in the intact pancreas. We developed a new method to determine the total number and the mean volume of the pancreatic islets, and we used this method to study the expansion of the islet mass in ob/ob mice (n = 8), using ob/+ mice (n = 8) as controls. The total islet volume was increased b...
Impaired Coronary and Renal Vascular Function in Spontaneously Type 2 Diabetic Leptin-Deficient Mice
BACKGROUND Type 2 diabetes is associated with macro- and microvascular complications in man. Microvascular dysfunction affects both cardiac and renal function and is now recognized as a main driver of cardiovascular mortality and morbidity. However, progression of microvascular dysfunction in experimental models is often obscured by macrovascular pathology and consequently demanding to study. T...
It has long been a matter of debate whether the hormone-sensitive lipase (HSL)-mediated lipolysis in pancreatic beta-cells can affect insulin secretion through the alteration of lipotoxicity. We generated mice lacking both leptin and HSL Lep(ob/ob)/HSL(-/-) and explored the role of HSL in pancreatic beta-cells in the setting of obesity. Lep(ob/ob)/HSL(-/-) developed elevated blood glucose level...
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