To examine the potential impact of fluid dynamic boundary layers on cutaneous ion exchange, we investigated how bulk flow of dilute Na+ solutions (< or = 1.0 mmol l-1) over the skin of intact frogs (Rana catesbeiana and Rana pipiens) affects cutaneous Na+ uptake (JNa(in)) and transepithelial potential (TEP). Cessation of stirring resulted in a 14-35% decrease in TEP and a 14-65% decrease in JNa...

SCHAEFER, KARL E., NANCY MCCABE, AND JUDITH WITHERS. Stress response in chronic hypercajmia. Am. J. Physiol. 214(3) : 543-548. 1968.-Respiratory acidosis induced by prolonged exposure of guinea pigs to 15% COz in 21y0 O2 was compensated after 3 days of exposure. Adrenal cortical response as measured by a rise of blood corticosteroids, adrenal cholesterol depletion, and lymphopenia was limited t...

Background: The main definitions of bronchopulmonary dysplasia (BPD), proposed by Jobe-Bancalari, Shennan et al., and Walsh et al., focus on oxygen (O2)-need and ventilatory support for the first weeks of life and at 36 weeks of post-menstrual age (PMA). Oxygen need at 36 weeks of PMA is sometimes due to intercurrent episodes (IEs) other than BPD. The aim of this retrospective study was to char...

Although reactive O2 species appear to participate in central nervous system (CNS) O2 toxicity, the exact roles of different reactive O2 species are undetermined. To study the contribution of extracellular superoxide anion (O2-) to CNS O2 toxicity we constructed transgenic mice overexpressing human extracellular superoxide dismutase (ECSOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) in ...

The aim of this study was to investigate whether treatment with mesenchymal stem cells (MSCs) could improve survival after radiation combined injury. Bone marrow MSCs (BMSCs) were isolated from femurs of B6D2F1/J female mice and were expanded and cultivated in hypoxic conditions (5% O2, 10% CO2, 85% N2) over 30 days. BMSCs were transfused to mice 24 hr after combined injury due to 60Co-γ-photon...

The production of sulfate in cloud droplets, and the attendant depletion of sulfur dioxide (SO2) oxidants were studied in wintertime orographic louds over southeastern Wyoming. By periodic (5-20 min) releases of SO 2 into the cloud the mixing ratio of SO 2 was raised to about double its background value of 0.7 parts per billion by volume (ppbv). Average values of the in-cloud reaction time, pse...

Mesothelioma is an aggressive tumor associated with asbestos exposure. Auranofin as an inhibitor of thioredoxin reductase (TrxR) affects many biological processes such as inflammation and proliferation. In the present study, we investigated the cellular effects of auranofin on patient-derived mesothelioma cells in relation to reactive oxygen species (ROS) and glutathione (GSH) levels. Basal Trx...

the emergency severity index (esi) is a five-level triage system that has shown promising reliability and validity. according to esi algorithm, in the presence of danger zone respiratory rate (rr), heart rate (hr) or oxygen (o2) saturation, patients should be up-triaged from esi level 3 to 2 hence, the current study aimed to investigate the value of the measurement of vital signs in predicting ...

We present 65 Sloan Digital Sky Survey (SDSS) spectra of 62 star-forming galaxies with oxygen abundances 12 + log O/H ∼ 7.5–8.4. Redshifts of selected galaxies are in the range z ∼ 0.36–0.70. This allows us to detect the redshifted Mg ii λ2797, λ2803 emission lines. Our aim is to use these lines for the magnesium abundance determination. The Mg ii emission was detected in ∼2/3 of the galaxies. ...

PX-12 (1-methylpropyl 2-imidazolyl disulfide) is an inhibitor of thioredoxin (Trx-1), which has antitumor effects. However, little is known about the toxicological effect of PX-12 on cancer cells. We investigated the anti-growth effects of PX-12 on A549 lung cancer cells in relation to reactive oxygen species (ROS) and glutathione (GSH) levels. Based on MTT assays, PX-12 inhibited the growth of...