High performance anion exchange chromatography was utilized to demonstrate extensive metabolism of tubercidin and formycin to their corresponding 5’-triphosphates in mouse leukemia EL4 cells and a concomitant decrease in cellular ATP. Efficient anabolism of formycin required the presence of an inhibitor (erythro9-(2-hydroxy-3-nonyl)adenine) of adenosine deaminase in the cellular incubations. Ac...
