Influenza nucleoprotein (NP) serves as a target antigen on abortively infected cells for cytotoxic T cells (TJ) cross-reactive for all type A influenza viruses, and it can also prime mice for such Tc. It is important to test the protective ability of NP-specific Tc clones in vivo in a productive influenza infection. In this report, we show that Tc clones of this antigenic specificity protect mi...

The antiprotein in an antipneumococcus horse serum resulting from intravenous injections of infected pleural exudate showed a precipitin type of reaction with pneumococcus nucleoprotein rather than the antitoxin type of response.

The skin and mucous membranes are the anatomical sites were most viruses are first encountered by the immune system. Previous experiments have suggested that striated muscle cells are unique among mammalian cell types in their capacity to take up and express free DNA in the absence of a viral vector or physical carrier. However, we have found that mice injected into the superficial skin with fr...

Transposases mediate transposition first by binding specific DNA end sequences that define a transposable element and then by organizing protein and DNA into a highly structured and stable nucleoprotein 'synaptic' complex. Synaptic complex assembly is a central checkpoint in many transposition mechanisms. The Tn5 synaptic complex contains two Tn5 transposase subunits and two Tn5 transposon end ...

Recent observations on conjugated proteins (l-6) raise the question as to whether the prevailing ideas concerning the nature of the attachment of nucleic acids with the proteins are valid. With certain exceptions it has generally been assumed that the nucleoproteins are salts of a polyvalent nucleic acid and a polyvalent base (protein) (7). The ideas that nucleoproteins are salt-like (polar), o...

The horizontally transferred chromosomal segments, which are the main source of genetic diversity among bacterial pathogens, are bound by the nucleoid protein H-NS, resulting in the formation of a nucleoprotein complex and the silencing of gene expression. The de-silencing or activation of virulence genes necessary for the colonization of enterohemorrhagic Escherichia coli is achieved mainly by...

Repeated injections of colloidal copper, hirudin, nucleoprotein, and casein, which have a definite retarding influence on tumor growth, given to mice during the process of wound healing do not produce any noticeable influence on the course of regeneration.