نتایج جستجو برای: nucleocytoplasmic shuttling

تعداد نتایج: 4663  

Journal: :The Journal of biological chemistry 2003
Zhan Xiao Amy M Brownawell Ian G Macara Harvey F Lodish

To investigate the subcellular distributions of Smad proteins, the intracellular mediators of transforming growth factor-beta family cytokines, we examined their sequences for nuclear export signals (NES). We found a leucine-rich NES-like motif (termed NES2) in the central linker region of the receptor-regulated Smads that is absent from the other two classes of Smads (Co-Smads and I-Smads). In...

Journal: :The FASEB Journal 2021

Bcl-2-associated athanogen-6 (BAG6) is a nucleocytoplasmic shuttling protein involved in quality control. We previously demonstrated that BAG6 essential for autophagy by regulating the intracellular localization of acetyltransferase EP300, and thus, modifying accessibility to its substrates (TP53 nucleus autophagy-related proteins cytoplasm). Here, we investigated function cytoplasm. First, loc...

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