Most epidemiological evidence supports the inverse association between use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) and colorectal cancer. Few studies have investigated the relation between use of aspirin and other NSAIDs and adenomatous polyps, which are recognized as precursors of colorectal cancer. We examined the association of adenomatous polyps and the dose and d...

BACKGROUND Idiosyncratic drug reactions such as hepatotoxicity and blood dyscrasias represent one of the major causes of drug withdrawal from the market. According to the reactive metabolite (RM) concept, this may be due to the metabolic activation of structural alerts (SAs), functionalities in the drug molecule that are susceptible to bioactivation resulting in RMs. The relationship, however, ...

Se presenta el caso de una mujer no atópica de 42 años de edad que había presentado varios episodios de urticaria generalizada y disnea tras comer marisco, langostinos y percebes, concretamente. La misma paciente había tolerado la ingesta de estos mismos alimentos en múltiples ocasiones entre los distintos episodios de anafi laxia. El estudio alergológico incluyó la realización de pruebas cután...

FLUNIXINMEGLUMINE Flunixinmeglumine (Banamine) is frequently used in horses for the treatment of colic and endotoxemia. It has not historically been used for treating lameness, due to a perceived inferiority to phenylbutazone for musculoskeletal pain. Comparative studies in horses with naturally occurring navicular disease have shown no significant differences in the analgesic effects of flunix...

BACKGROUND AND PURPOSE Limited studies have investigated the risk of cerebrovascular events associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in subjects at high risk. We examined the short-term (defined as 30-day period) effect of selective and nonselective NSAIDs use on the risk of ischemic and hemorrhagic stroke in patients with hypertension. METHODS We conducted a c...

While aspirin may offer protection, other non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) can cause serious cardiovascular side effects and complications. This has led to a general "black box" warning for cardiovascular adverse events for NSAIDs. This review explores the different mechanisms underlying the protective effects of aspirin, the NSAID associated renovascular effects causi...

BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed in the community pharmacy. Their systemic administration has been related to significant adverse effects. The aim of this study was to evaluate the efficacy of topical NSAIDs in managing mild to moderate musculoskeletal pain versus systemic administration or combination of both routes. METHODS This was a prospecti...