Rupseh Dudhe *, Pramod Kumar Sharma, Prabhakar Verma, Anshu Chaudhary a Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, NH-58, Baghpat Bypass Crossing, Meerut (U. P.), India250005. Vishveshwarya Institute of Medical Science Dadri, Gautambudh Nagar (U.P.) India-203207. Uttarakhand Technical University, Dehradun (Uttarakhand), India248007. NIMS University, S...

Medical therapy of patients with malignancy requires a paradigm shift through development of new drugs with a good safety record and novel mechanisms of activity. While there is no dearth of such molecules, one particular agent, "reovirus" is promising by its ability to target cancer cells with aberrant signaling pathways. This double-stranded RNA virus has been therapeutically formulated and h...

PURPOSE In spite of all the efforts and researches on anticancer therapeutics, an absolute treatment is still a myth. Therefore, it is necessary to utilize novel technologies in order to synthesize smart multifunctional structures. In this study, for the first time, we have evaluated the anticancer effects of BCc1 nanocomplex by vitro and in vivo studies, which is designed based on the novel na...

Prostate cancer is a major public health problem worldwide. For the development of potential anti-prostate cancer agents, a series of novel arylpiperazine derivatives containing the saccharin moiety based on previous studies was designed, synthesized, and evaluated in prostate (PC-3, LNCaP, and DU145) cancer cell lines for their anticancer activities. The majority of the compounds exhibited exc...

Studies indicate that diabetics are more likely to develop cancer, especially of the pancreas or colon, or hepatocellular carcinoma. Tumor genesis is promoted by high insulin and glucose levels pancreas, in T2DM (Saito et al., 2013; Zheng et al., 2013; Wang et al., 2015). Metformin, a commonly used drug for T2DM, reduces the incidence of various types of neoplasm. However, much less is known ab...

Background: The ubiquitin-proteasome pathway plays an important role in selective protein degradation and regulates multiple cellular processes, including cell cycle progression, proliferation and apoptosis. Cancer cells are more sensitive to the pro-apoptotic effects of proteasome inhibition than normal cells, hence, proteasome inhibitors can be used as novel anticancer drugs. Further, influen...

Cancer is a great concern in the public health and development of novel therapeutic agent or strategy become urgently. Anticancer peptides (ACPs) have become promising anticancer drug candidate molecules due to their several extraordinary properties, such as small size, high activity, low immunogenicity, good biocompatibility, diversity of sequence and more modification sites for the functional...

The search for novel and effective cancer chemopreventive agents has led to the identification of various naturally occurring compounds one of which is resveratrol (trans-3,4',5-trihydroxystilbene), a phytoalexin derived from the skin of grapes and other fruits. Resveratrol is known to have potent anti-inflammatory and antioxidant effects and to inhibit platelet aggregation and the growth of a ...

UNLABELLED The anticancer activity of aziridinyl-quinones is mainly attributed to their NAD(P)H quinone oxidoreductase 1 (NQO1)-catalyzed two-electron reduction into DNA-alkylating products. However, little is known about their cytotoxicity in primary cells, which may be important in understanding their side effects. We found that the cytotoxicity of aziridinyl-unsubstituted quinones (n = 12)...

Vitamin E is composed of two structurally similar compounds: tocopherols (TPs) and tocotrienols (T3). Despite being overshadowed by TP over the past few decades, T3 is now considered to be a promising anticancer agent due to its potent effects against a wide range of cancers. A growing body of evidence suggests that in addition to its antioxidative and pro-apoptotic functions, T3 possesses a nu...