OBJECTIVE To compare the effects of a bolus infusion of hypertonic saline hydroxyethyl starch with the effects of normal saline (placebo) on intracranial pressure (ICP) and cerebral perfusion pressure in patients with spontaneous subarachnoid hemorrhage. DESIGN AND SETTING Prospective, randomized, single-blinded, placebo-controlled study in a university hospital. PATIENTS A total of 22 mech...

Duburcq and colleagues, in their article published in Critical Care, showed improved oxygenation, hemodynamic parameters, and microvascular reactivity in an experimental porcine endotoxic shock model with use of hypertonic sodium lactate 11.2% [1]. We applaud the authors for embarking on the arduous quest for the ideal resuscitative fluid, which has historically been fraught with shortcomings. ...

Method: The present double-blind clinical trial recruited 213 patients presenting with fractured limbs to emergency departments. The first group of patients received 1 micg/kg of intravenous fentanyl citrate from a solution of 50 micg/ml and 5 ml of normal saline in nebulized form (group A), and the second group intravenously received 5 ml of normal saline and 4 micg/kg of 50 micg/ml solution o...

OBJECTIVE To determine whether nebulized 3% hypertonic saline with epinephrine is more effective than nebulized 0.9% saline with epinephrine in the treatment of bronchiolitis in the emergency department. DESIGN Randomized, double-blind, controlled trial. SETTING Single-center urban pediatric emergency department. PARTICIPANTS Infants younger than 12 months with mild to moderate bronchioli...

the aim of this study was to compare the effectiveness of fenugreek (trigonella foenum-graecum) with that of lovastatin in restoration of endothelia function in the aorta taken form aged n-mair rats. for this purpose, 4 groups of old n-mari rats were used (n=6), normal saline treated control group, lovastatin (10 mg/kg, orally) and fengreek seed powder in normal saline suspension (100 or 500 mg...

introduction: to evaluate the effects of using sodium hypochlorite irrigant on pull-out bond strength of self-etch and self-adhesive resin cements to dentin. methods: sixty intact premolars were decoronated and the root canals were prepared by step-back technique. the teeth were divided into two groups according to the irrigant used during root canal treatment: 5.25% sodium hypochlorite and nor...