In a previous study, we reported that two kaempferol glycosides isolated from Laurus nobilis L., kaempferol-3-O-alpha-L-(2'',4''-di-E-p-coumaroyl)-rhamnoside (C2) and kaempferol-3-O-alpha-L-(2''-E-p-coumaroyl-4''-Z-p-coumaroyl)-rhamnoside (C3), showed strong antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. Thereafter we fo...

The purpose of this study is to predict human jejunal permeability (P(eff)) and fraction absorbed in human (%F(a)) for a group of antibacterial fluoroquinolones (FQs), by using a biophysical model based on measured Caco-2 permeability. The predicted P(eff) (in 10(-4) cm · s(-1) units) ranged from 0.7 (norfloxacin) to 4.5 (pefloxacin). The calculated %F(a) for norfloxacin = 51% (lit. 35%) and fo...

The uptakes of norfloxacin by quinolone-resistant and -susceptible strains of Serratia marcescens were almost the same and 50% inhibitory concentrations for DNA gyrase and the MICs of quinolones were correlated, suggesting that DNA gyrase alterations are the basis of quinolone resistance.

A series of N-nicotinoyl-1-ethyl-6-fluoro-1,4-dihydro-7-piperazin-1-yl-4-oxoquinoline-3-carboxylates has been synthesized and evaluated for antibacterial activity. Norfloxacin was reacted with thionyl chloride, to yield norfloxacin acid chloride which was used immediately in next step by reacting with respective alcohols to furnish the corresponding esters i.e. 1-ethyl-6-fluoro-1,4-dihydro-7-pi...

Background: Concomitant oral administration of NFX with TNZ may affect NFX absorption and consequently its blood concentration and pharmacological effect. Objective: The present study was undertaken to investigate the effect of TNZ on the pharmacokinetics of NFX in healthy volunteers. Methods: This study was conducted as an open-label, randomized, two-way crossover experimental design. After an...

Background: Concomitant oral administration of NFX with TNZ may affect NFX absorption and consequently its blood concentration and pharmacological effect. Objective: The present study was undertaken to investigate the effect of TNZ on the pharmacokinetics of NFX in healthy volunteers. Methods: This study was conducted as an open-label, randomized, two-way crossover experimental design. After an...

Co-administration of norfloxacin (NFX) and tinidazole (TNZ) has been used for the treatment of gastrointestinal and urinary tract infections. Concomitant oral administration of NFX with TNZ may affect NFX absorption and consequently its blood concentration and pharmacological effect. The present study was undertaken to investigate the effect of TNZ at the usual clinical dosage on the pharmacoki...