نتایج جستجو برای: nonstructural protein 4 nsp4
تعداد نتایج: 2376592 فیلتر نتایج به سال:
Herein we present the synthesis of a novel type of peptidomimetics composed of repeating diaminopropionic acid residues modified with structurally diverse heterobifunctional polyethylene glycol chains (abbreviated as DAPEG). Based on the developed compounds, a library of fluorogenic substrates was synthesized. Further library deconvolution towards human neutrophil serine protease 4 (NSP4) yield...
Corona virus disease 2019 (COVID-19) endemic has havoc on the world; causative of pandemic is SARS CoV-2. Pharmaceutical companies and academic institutes are in continuous efforts to identify anti-viral therapy or vaccines, but most significant challenge faced highly evolving genome CoV-2, which imparting evolutionary selective benefits virus. To understand viral mutations, we have retrieved n...
Chikungunya virus (CHIKV; genus Alphavirus, family Togaviridae) has recently caused several major outbreaks affecting millions of people. There are no licensed vaccines or antivirals, and the knowledge of the molecular biology of CHIKV, crucial for development of efficient antiviral strategies, remains fragmentary. CHIKV has a 12 kb positive-strand RNA genome, which is translated to yield a non...
We established a rapid, specific technique for detecting alphaviruses using a replicon-defective reporter gene assay derived from the Sindbis virus XJ-160. The pVaXJ expression vector containing the XJ-160 genome was engineered to form the expression vectors pVaXJ-EGFP expressing enhanced green fluorescence protein (EGFP) or pVaXJ-GLuc expressing Gaussia luciferase (GLuc). The replicon-defectiv...
background: hospitals in iran are not prepared for disasters the aim of this study was to determine the effect of training functional and nonstructural hospital safety to nurses and their intervention on hospital preparedness in psychiatric razi hospital and day hospital in tehran based on hospital safety index (hsi). materials and methods: this semi-experimental study included nurse ma...
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