نتایج جستجو برای: non ulcerogenic
تعداد نتایج: 1317118 فیلتر نتایج به سال:
We recently reported that, compared to loxoprofen (LOX, an non-steroidal anti-inflammatory drug), the LOX derivative fluoro-loxoprofen (F-LOX) is less ulcerogenic but has similar anti-inflammatory activity. Our previous in vitro studies suggested that both LOX and F-LOX are pro-drugs, the active metabolites of which are their trans-alcohol forms. In this study, we compared the pharmacokinetic...
Novel oral anticoagulants (NOACs), which include direct thrombin inhibitor (dabigatran) and direct factor Xa inhibitors (rivaroxaban, apixaban and edoxaban), are gaining popularity in the prevention of embolic stroke in non-valvular atrial fibrillation as well as in the prevention and treatment of venous thromboembolism. However, similar to traditional anticoagulants, NOACs have the side effect...
در این پایان نامه با استفاده از تابع لیاپانوف فازی، به طراحی کنترل کننده pdc و non-pdc برای سیستم های فازی افاین پرداخته می شود. استفاده از تابع لیاپانوف فازی باعث برقراری راحت تر شرایط پایداری و در نتیجه کاهش محافظه کاری می شود. همچنین استفاده از این تابع لیاپانوف به منظور پایدارسازی، طیف گسترده تری از سیستم های فازی افاین را شامل می شود. از طرفی استفاده از کنترل کننده non-pdc باعث می شود شرای...
A series of anti-inflammatory derivatives containing an N-acyl hydrazone subunit (4a-e) were synthesized and characterized. Docking studies were performed that suggest that compounds 4a-e bind to cyclooxygenase (COX)-1 and COX-2 isoforms, but with higher affinity for COX-2. The compounds display similar anti-inflammatory activities in vivo, although compound 4c is the most effective compound fo...
In search of novel gastroprotective agents, mangiferin, a naturally occurring glucosylxanthone from Mangifera indica L. (Anacardiaceae), was evaluated in mice on gastric injury induced by ethanol and indomethacin. The effects of mangiferin on gastric mucosal damage were assessed by determination of changes in mean gastric lesion area or ulcer score in mice and on gastric secretory volume and to...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید