The effects of three non-steroidal anti-inflammatory drugs, ibufenac, sulindac and mepirizole, on the renal excretion of sulfamethizole in rats were investigated, in order to clarify the mechanisms involved. The clearance ratio of sulfamethizole was markedly decreased after infusion of ibufenac, while sulindac or mepirizole had no effect on the clearance ratio of sulfamethizole. From this resul...

An increasing number of nonsteroidal anti-inflammatory drugs (NSAIDs) are available to treat a variety of conditions. There exist little comparative data examining efficacy for all NSAIDs for a particular illness. The major factors governing selection of these agents relate to the patient's condition and the drug's characteristics. Once efficacy has been established, selection of an NSAID is th...

wice in the past year, headlines across the nation have ighlighted the publication of studies suggesting that nonteroidal anti-inflammatory drugs (NSAIDs) inhibit the ardioprotective effects of aspirin (1,2). Based on these esults, some experts have strongly recommended that atients avoid taking these medications in combination 3,4). These studies and the resultant publicity place cliniians in ...

We report a prospective, randomised, controlled trial of the effect of either a non-steroidal anti-inflammatory drug (diclofenac sodium) or physiotherapy on the recovery of knee function after arthroscopy. At 42 days after surgery there was no significant benefit from either form of postoperative treatment compared with the control group. Complications attributable to the anti-inflammatory drug...

Steroidal glycoalkaloids (SGAs) are specialized metabolites found in members of Solanum species, and also known as toxic substances food crops such tomato (Solanum lycopersicum), potato tuberosum), eggplant melongena). SGA biosynthesis can be divided into two main parts: formation steroidal aglycones, which derived from cholesterol, glycosylation at the C-3 hydroxy group. This review focuses on...

Results Forty-one patients were tested, all with negative results. Thirty seven of them (90%) were contacted and 28 (76%) remembered the tested drug’s name. Twelve of them (32%) had used the drug again without any reaction. Twenty five patients were not re-exposed: 18 did not need, 4 were afraid of a new reaction and 3 used another alternative. Of the 4 patients who were afraid to use the drug ...