Parkinson’s disease is one of the most common movement disorders characterized by bradykinesia, rigidity, resting tremor and postural instability (Fahn, 2003). It affects nearly five million elderly people worldwide (de Lau & Breteler, 2006). As the population ages, the incidence and prevalence of Parkinson’s disease are expected to increase dramatically (Dorsey et al., 2007; Tanner & Goldman, ...

We give a short and elementary proof of the non-realizability mapping class group via homeomorphisms. This was originally established by Markovic, resolving conjecture Thurston. With tools in this paper, we also obtain some rigidity results for actions on Euclidean spaces.

Using a representative-household search and matching model with endogenous labor force participation, we study the cyclicality of market transition rates between employment, unemployment, nonparticipation. When interpreted through lens model, cyclical behavior implies that participation margin is strongly countercyclical: household's incentive to send workers falls in expansions. We identify tw...

Rigidity investigations in virtual Lego models In this thesis, we investigate the potential improvement of the algorithms detecting rigid structures in virtual Lego models in the computer application Lego Digital Designer. First, the previously achieved results are presented. This mainly involves a heuristic triangle rigidity detection algorithm described in a Bachelor’s thesis. Then, the two t...

Wage rigidity – the observation that wages cannot be adjusted downwards – has important implications for labour markets and macroeconomic performance. Empirical evidence on the extent, causes and consequences of wage rigidity on the individual level is relatively scant, however. This Feature presents articles that apply a new methodology to estimate the incidence and extent of nominal and real ...

Based on the theoretical model of rigidity correlation method, the study on application was carried out with Chinese Liyuan face rockfill dam as example. The linear relation equations between the rockfill rigidity and density measured by pit method were established, and the regression performance and accuracy of rigidity correlation method were analyzed by calculating the inversion values of de...

AIM To estimate whether laxatives prescribed for constipation in Parkinson's disease (PD) could moderate rigidity. Constipation predates diagnosis of PD by decades. Deposition of misfolded protein may begin in the gut, driven by dysbiosis. Successive antimicrobial exposures are associated with cumulative increase in rigidity, and rigidity has biological gradients on circulating leukocyte-subset...

BACKGROUND AND PURPOSE Action tremor may occur in patients with Parkinson's disease and cause misdiagnosis with other movement disorders such as essential tremor and dystonia. Data on the frequency of action tremor in Parkinson's disease and on the relationships with other motor and non-motor signs are limited. METHODS A cross-sectional study of 237 patients with Parkinson's disease staging 1...