This article investigates the role of historical references and arguments in current policy debate on non-invasive prenatal testing (NIPT) Germany. It analyses major documents opinion statements, including recent parliamentary (2019). The implementation NIPT is accompanied by concerns strong criticism, particularly Many perceive new test to be a problematic step that facilitates selective pract...

Abstract Since 2012, non-invasive prenatal testing (NIPT) using cell-free DNA from maternal plasma is applied all over the world as highly efficient first-line or contingent screening approach for trisomy 13, 18 and 21. With further technical development has expanded to other genetic conditions such sex chromosome anomalies (SCAs), rare autosomal trisomies (RATs), microdeletions/microduplicatio...

OBJECTIVE To develop a Canadian consensus document on maternal screening for fetal aneuploidy (e.g., Down syndrome and trisomy 18) in singleton pregnancies. OPTIONS Pregnancy screening for fetal aneuploidy started in the mid 1960s, using maternal age as the screening test. New developments in maternal serum and ultrasound screening have made it possible to offer all pregnant patients a non-in...

With the discovery of existing circulating cell-free fetal DNA (ccffDNA) in maternal plasma and the advent of next-generation sequencing (NGS) technology, there is substantial hope that prenatal diagnosis will become a predominately non-invasive process in the future. At the moment, non-invasive prenatal testing (NIPT) is available for high-risk pregnancies with significant better sensitivity a...

Although rare, umbilical cord cysts may be associated with prenatal aneuploidy and foetal developmental anomaly. If unresolved, they affect growth support a risk of progressive or sudden vascular compromise. In this report, we discuss the case 33-year-old woman who presented large septate cyst detected incidentally during routine morphology scanning. The patient had low-risk first-trimester com...