OBJECTIVE To evaluate feasibility, safety, and efficacy of overnight closed-loop insulin delivery in free-living youth with type 1 diabetes. RESEARCH DESIGN AND METHODS Overnight closed loop was evaluated at home by 16 pump-treated adolescents with type 1 diabetes aged 12-18 years. Over a 3-week period, overnight insulin delivery was directed by a closed-loop system, and on another 3-week per...

T HE MANAGEMENT OF diabetes poses challenges at all levels, from affected individuals to society as a whole. Microvascular complications of diabetes have been attributed to poor glycemic control since the Joslin era. This hypothesis was confirmed for patients with type 1 diabetes mellitus by the results of the Diabetes Control and Complications Trial and for patients with type 2 diabetes mellit...

Genetic related health problems are often interrelated. Current practices to establish associations between diseases are expensive and rarely can reflect underlying molecular mechanisms, We propose a general framework to associate diseases by networking pathways. By applying our method on association study of non-insulin dependent diabetes mellitus (NIDDM) and obesity, we demonstrate that our m...

OBJECTIVE Youth with Type 1 diabetes (T1D) from single-parent families have poorer glycemic control; a finding confounded with socioeconomic status (SES). Family density (FD), or youth:adult ratio, may better characterize family risk status. METHODS Structural equation modeling assessed the relation of single-parent status, SES, and FD to parenting stress, diabetes-related conflict, parental ...

AIM To examine incidence and trends of Type 1 diabetes worldwide for the period 1990-1999. METHODS The incidence of Type 1 diabetes (per 100 000/year) was analysed in children aged <or= 14 years from 114 populations in 112 centres in 57 countries. Trends in the incidence of Type 1 diabetes were analysed by fitting Poisson regression models to the dataset. RESULTS A total of 43,013 cases wer...

BACKGROUND The aim of the study was to estimate the effect of the accumulation of major life events (MLE) in childhood and adulthood, in both the private and working domains, on risk of type 2 diabetes mellitus (T2DM). Furthermore, we aimed to test the possible interaction between childhood and adult MLE and to investigate modification of these associations by educational attainment. METHODS ...

OBJECTIVE The Registry for Type 1 Diabetes Mellitus in Italy (RIDI) Study Group was established to coordinate the registries of type 1 diabetes in Italy. This report is based on 3,606 children younger than 15 years diagnosed with type 1 diabetes and prospectively registered during 1990-1999 by nine centers, covering >35% of the Italian population. RESEARCH DESIGN AND METHODS Registries were p...

CONTEXT Patients with schizophrenia have an increased risk of type 2 diabetes mellitus. However, very few studies have dealt with the association of type 1 diabetes and schizophrenia. Preliminary evidence points to a possible inverse association. OBJECTIVE To investigate the incidence of schizophrenia in a nationwide cohort of patients with type 1 diabetes born in 1950 through 1959 in Finland...

A questionnaire returned by 250 (71.4%) of the 350 general practices in Northern Ireland indicated that although only 34 practices had special arrangements for seeing their diabetic patients, 178 practices stated that they would like to be more involved in the care of their non-insulin-dependent diabetes mellitus (NIDDM) patients. One hundred and eight practices felt the same way about their in...

A preliminary group matched comparison study of periodontal status was conducted among Indian participants who had type 1 diabetes mellitus (T1DM) and non-diabetic controls. The mean number of bleeding sites, gigival index score, number of periodontal pocket's and number of clinical loss attachment sites were all significantly higher in cases compared to controls. This study provides evidence t...