The prevention of malaria infections is one of the most important functions that any clinician can perform for those traveling to tropical geographic regions where malaria risks are present. The prophylaxis question has become complicated by continued emergence of chloroquine-resistant strains of Plasmodium falciparum, the recent appearance of Plasmodium vivax resistance, and the availability o...

Severe malaria is a medical emergency that requires urgent recognition and treatment, because it may rapidly progress to serious complications and death. We report a case of imported severe malaria tropica in an adult traveller, with a parasitemia of 20%, complicated by acute renal failure. Patient was initially misdiagnosed by a physician unaware of the importance of patients travel history, a...

prophylaxis were 34.6% (n=35), while the rest were on no prophylaxis. Complicated cases were: 5 cases presented with cerebral malaria, one of them succumbed while the rest recovered completely; 4 presented with uremia and were referred for dialysis, one of them passed away after the first dialysis session. Other clinical presentations were seen such as: upper gastro-intestinal bleeding, diarrhe...

Malaria is a devastating and complicated disease caused by the Plasmodium parasite. P. falciparum has developed a mechanism for evasion of immune responses and clearance from the blood stream by adhering to endothelial cells in different organs. This is achieved by the expression of P. falciparum erythrocyte membrane protein 1 (PfEMP1) proteins on the surface of infected red blood cells (iRBCs)...

We describe the case of a 14-year-old Caucasian male, a resident in the Democratic Republic of the Congo, who was observed in Portugal with severe Plasmodium falciparum malaria with high-level parasitemia and severe thrombocytopenia. The course was complicated by bilateral sixth cranial nerve palsy during acute malaria, followed by the appearance of delayed cerebellar ataxia during the recovery...

Nitric oxide (NO) is thought to be an important mediator and critical signaling molecule for malaria immunopathology; it is also a target for therapy and for vaccine. Inducible nitric oxide synthase (iNOS) is synthesized by a number of cell types under inflammatory conditions. The most relevant known triggers for its expression are endotoxins and cytokines. To date, there have been conflicting ...

BACKGROUND Severe falciparum malaria may be complicated by prolonged haemolysis and recurrent fever after parasite clearance. However, their respective etiologies are unclear and challenging to diagnose. We report the first case of severe falciparum malaria followed by prolonged haemolytic anaemia and rhinomaxillary mucormycosis in a previously healthy adult male. CASE PRESENTATION A 30-year ...

introduction malaria is the most important parasitic infection, which is now spread all over the globe. malaria infections with more than two species, especially plasmodium falciparum and p. vivax, are common, but infections with p. malariae and p. falciparum are rare. discussion mixed malaria infection is not uncommon, and it needs to be diagnosed and treated effectively in order to control th...

Suspected malaria cases in Africa increasingly receive a rapid diagnostic test (RDT) before antimalarials are prescribed. While this ensures efficient use of resources to clear parasites, the underlying cause of the individual's fever remains unknown due to potential coinfection with a non-malarial febrile illness. Widespread use of RDTs does not necessarily prevent over-estimation of clinical ...

Introduction Malaria remains a widespread health problem with huge burden. Severe or complicated malaria is highly lethal and encompasses variety of pathological processes, including immune activation, inflammation, dysmetabolism. Previously, we showed that adrenal hormones, in particular glucocorticoids (GCs), play critical roles to maintain disease tolerance during Plasmodium infection mice. ...