Osteoarthritis (OA) is a degenerative and inflammatory disease of synovial joints that is characterized by the loss of articular cartilage, for which there is increasing interest in natural remedies. Curcumin (diferuloylmethane) is the main polyphenol in the spice turmeric, derived from rhizomes of the plant Curcuma longa. Curcumin has potent chemopreventive properties and has been shown to inh...

This study aimed to investigate the effects of certain nutrient medium types enhanced with plant-growth regulators on direct inductionof somatic embryogenesis in vegetative strains produced and propagated from a tissue culture Digitalis purpurea. The results showthat MS was superior other tested media-B5, LS, 5C01—in terms days required initiate somaticembryogenesis induction rate. In contrast,...

The objective of this study was to investigate the effect cytokinins benzylaminopurine (BAP) and Kinetin on in vitro shootregeneration shoot tips Polyscias balfouriana marginata. Shoot were cultured Murashige Skooge (1962) medium (MS) supplemented with various concentrations BAP at 0.0, 0.75, 1.5, 3, 6 mg/L for both. Results showed that marginata responded positively growth regulators applicati...

PURPOSE To determine the corneal regenerative capacity of sequentially generated primary, secondary, and tertiary limbal explant outgrowths in a limbal stem cell deficiency (LSCD) surgical model. METHODS Two-millimeter-long limbal shallow biopsies were surgically excised from the upper quadrant of the right eye of rabbits and set on preserved amniotic membrane for explant culture. After the g...

Human cytomegalovirus (CMV) infection of the developing fetus can result in adverse pregnancy outcomes including death in utero. Fetal injury results from direct viral cytopathic damage to the CMV-infected fetus, although evidence suggests CMV placental infection may indirectly cause injury to the fetus, possibly via immune dysregulation with placental dysfunction. This study investigated the e...

BACKGROUND The major histocompatibility complex (MHC) is the most important genomic region that contributes to the risk of graft versus host disease (GVHD) after haematopoietic stem cell transplantation. Matching of MHC class I and II genes is essential for the success of transplantation. However, the MHC contains additional genes that also contribute to the risk of developing acute GVHD. It is...

PIWOWARCZYK BARBARA, PINDEL ANNA, MUSZYŃSKA EWA. 2016. Callus Induction and Rhizogenesis in Lathyrus sativus L. Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 64(1): 123–128. Grass pea (Lathyrus sativus L.) is a leguminous plant distinguished by great resistance to abiotic and biotic stresses that can become a valuable source of protein feed in the nearest future. Howev...

Explants are excellent systems for studying homeostasis in cartilage. The systems are very useful in pharmacological studies involving OA-treatment and in studies of repair mechanisms during injury to hyaline cartilage. The purpose of this study was to evaluate the reparative processes occurring in a young age porcine cartilage explant model examining tissue by Light (LM) and Transmission Elect...

A transmembrane extracellular matrix receptor of the integrin family, alpha 6 beta 4, is a component of the hemidesmosome, an adhesion complex of importance in epithelial cell-connective tissue attachment (Stepp, M. A., S. Spurr-Michaud, A. Tisdale, J. Elwell, and I. K. Gipson. 1990. Proc. Natl. Acad. Sci. USA. 87:8970-8974; Jones, J. C. R., M. A. Kurpakus, H. M. Cooper, and V. Quaranta. 1991. ...