BACKGROUND There is an unmet need to develop an innovative cardioprotective modality for acute myocardial infarction, for which interventional reperfusion therapy is hampered by ischemia-reperfusion (IR) injury. We recently reported that bioabsorbable poly(lactic acid/glycolic acid) (PLGA) nanoparticle-mediated treatment with pitavastatin (pitavastatin-NP) exerts a cardioprotective effect in a ...

Herniation of the nucleus pulposus (NP) from lumbar intervertebral discs commonly results in radiculopathic pain possibly via a neuroinflammatory response. NP sensitizes dorsal horn neuronal responses but it is unknown whether this reflects a central or peripheral sensitization. To investigate central sensitization we tested if NP enhances windup—the progressive increase in the response of a no...

Background: Placebo and nocebo responses have important consequences for the development of pharmaceutical drugs design randomized controlled trials (RCTs). They can lead to incorrect measurement treatment-related efficacy adverse effects (AEs). Objectives: The goal this study was evaluate frequency magnitude placebo in placebo-controlled RCTs non-tumor necrosis factor (TNF) biologics Janus kin...

Heavy noun phrase shift refers to the phenomenon where a “heavy” noun phrase (NP) is displaced to the right of its canonical position. In English, heavy NP shift most commonly refers to the object (in square brackets) being found at the right edge of the sentence, to the right of indirect objects, adverbs, prepositions, etc. (1) I gave _ to the students [presents that I had brought back from Sp...