نتایج جستجو برای: nnos

تعداد نتایج: 2006  

2017
Saidan Ding Weishan Zhuge Xuebao Wang Jianjing Yang Yuanshao Lin Chengde Wang Jiangnan Hu Qichuan Zhuge

Insulin-like growth factor I (IGF-I) has been positively correlated with cognitive ability. Cognitive decline in minimal hepatic encephalopathy (MHE) was shown to be induced by elevated intracranial dopamine (DA). The beneficial effect of IGF-I signaling in MHE remains unknown. In this study, we found that IGF-I content was reduced in MHE rats and that IGF-I administration mitigated cognitive d...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
K Joseph Hurt Sena F Sezen Hunter C Champion Julie K Crone Michael A Palese Paul L Huang Akira Sawa Xiaojiang Luo Biljana Musicki Solomon H Snyder Arthur L Burnett

A key role for nitric oxide (NO) in penile erection is well established, but the relative roles of the neuronal NO synthase (nNOS) versus endothelial forms of NOS are not clear. nNOS- and endothelial NOS-deficient mice maintain erectile function and reproductive capacity, questioning the importance of NO. Alternatively, residual NO produced by shorter transcripts in the nNOS(-/-) animals might ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Samie R Jaffrey Fabio Benfenati Adele M Snowman Andrew J Czernik Solomon H Snyder

The specificity of the reactions of nitric oxide (NO) with its neuronal targets is determined in part by the precise localizations of neuronal NO synthase (nNOS) within the cell. The targeting of nNOS is mediated by adapter proteins that interact with its PDZ domain. Here, we show that the nNOS adapter protein, CAPON, interacts with synapsins I, II, and III through an N-terminal phosphotyrosine...

Journal: :Learning & memory 1997
V Lev-Ram Z Nebyelul M H Ellisman P L Huang R Y Tsien

Extensive pharmacological evidence suggests that nitric oxide (NO) is a crucial transmitter for cerebellar long-term depression (LTD), a long-lasting decrease in efficacy of the synapses from parallel fibers onto Purkinje neurons, triggered by coincident presynaptic activity and postsynaptic depolarization. We now show that LTD cannot be induced in Purkinje neurons under whole-cell patch clamp ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1998
G D Thomas M Sander K S Lau P L Huang J T Stull R G Victor

The neuronal isoform of nitric oxide synthase (nNOS) is highly expressed in mammalian skeletal muscle, but its functional role has not been defined. NO has been implicated in the local metabolic regulation of blood flow in contracting skeletal muscle in part by antagonizing sympathetic vasoconstriction. We therefore hypothesized that nNOS in skeletal muscle is the source of the NO mediating the...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شهرکرد - دانشکده دامپزشکی 1394

جهت ارزیابی بیان ژن نیتریک اکساید سنتتازها و محصول نیتریک اکساید در مغز (قدامی، میانی و خلفی) جوجه های مبتلا به هیپرتانسیون ریوی (ناشی از سرما)، تعداد 48 قطعه جوجه ی نر نژاد راس در دو گروه شاهد و تحت استرس سرما (هیپرتانسیون ریوی ناشی از سرما) به مدت 42 روز پرورش داده شدند، پس از کشتار نمونه هایی از سه قسمت مغز (قدامی، میانی و خلفی) و قلب گرفته شد. سپس میزان بیان ژن های,enos nnos و inos و همچنین...

Journal: :The Journal of biological chemistry 2009
Mohammad Mahfuzul Haque Mohammed Fadlalla Zhi-Qiang Wang Sougata Sinha Ray Koustubh Panda Dennis J Stuehr

Nitric-oxide synthases (NOSs) are calmodulin-dependent flavoheme enzymes that oxidize l-Arg to nitric oxide (NO) and l-citrulline. Their catalytic behaviors are complex and are determined by their rates of heme reduction (k(r)), ferric heme-NO dissociation (k(d)), and ferrous heme-NO oxidation (k(ox)). We found that point mutation (E762N) of a conserved residue on the enzyme's FMN subdomain cau...

Journal: :American journal of physiology. Heart and circulatory physiology 2012
Moriel H Vandsburger Brent A French Christopher M Kramer Xiaodong Zhong Frederick H Epstein

Within cardiomyocytes, endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) are thought to modulate L-type calcium channel (LTCC) function and sarcoplasmic reticulum calcium cycling, respectively. However, divergent results from mostly invasive prior studies suggest more complex roles. To elucidate the roles of nNOS and eNOS in vivo, we applied noninvasive cardiac ...

2013
Nick J. Spencer

It is well established that the intrinsic pacemaker mechanism that generates cyclical colonic migrating motor complexes (CMMCs) does not require endogenous nitric oxide (NO). However, pharmacological blockade of endogenous NO production potently increases the frequency of CMMCs, suggesting that endogenous NO acts normally to inhibit the CMMC pacemaker mechanism. In this study, we investigated w...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2009
T M C Pereira C M Balarini I V Silva A M Cabral E C Vasquez S S Meyrelles

Nitric oxide (NO) influences renal blood flow mainly as a result of neuronal nitric oxide synthase (nNOS). Nevertheless, it is unclear how nNOS expression is modulated by endogenous angiotensin II, an inhibitor of NO function. We tested the hypothesis that the angiotensin II AT1 receptor and oxidative stress mediated by NADPH oxidase contribute to the modulation of renal nNOS expression in two-...

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