596 VOLUME 11 | NUMBER 6 | JUNE 2005 NATURE MEDICINE persistently activated in a human disease called anaplastic large cell lymphoma10. Chromosomal translocations join the nucleoplasmin gene to the gene that encodes ALK kinase, producing the persistently active NMP-ALK oncogene. To investigate the role of STAT3 in malignant transformation by NMP-ALK and in cancer cell survival, Chiarle et al.5 ...

Sir, AdeABC, a resistance–nodulation–cell division (RND)-type efflux pump, is an attractive research target as a cause of multiple antibiotic resistance in Acinetobacter baumannii. The overexpression of the adeB gene encoding the AdeB efflux protein has previously been associated with multidrug resistance in various A. baumannii strains. – 3 These reports led us to perform a study in a group of...

A 'top down' synthesis of carbon and hexagonal boron nitride (h-BN) nano-scrolls has been developed using the shear forces within dynamic thin films of N-methyl-2-pyrrolidone (NMP) generated on a rapidly rotating spinning disc processor (SDP), along with a theoretical understanding of the formation of the scrolls.

An efficient user-friendly method of acylation of Grignard reagents to selectively synthesize ketones is presented, which is assisted by simple amides such as NMP, or DMF. The present chemoselective method tolerates a variety of functional groups such as ketone, ester, nitrile and other functional groups.