This case report describes a 10-year-old castrated male Russian Blue cat who was referred to the hospital for respiratory distress and coughing. Tests FeLV FIV infection were negative. Pleural fluid removed subjected cytological lymphocyte clonality analysis. Thoracic radiography ultrasonography confirmed atelectasis in some pulmonary lobes. The diagnosed with stage III small- medium-cell T cel...

the median overall survival in glioblastoma multiforme is usually less than one year. long-term survival is rare and is seen in only 3%-6% of gbm patients. the present study reports the characteristics and treatment outcomes of six cases of glioblastoma multiforme with long-term survival. a literature review is also presented. between 1990 and 2008, 217 glioblastoma multiforme patients have bee...

N-nitroso compounds (NOCs) may be implicated in human colon carcinogenesis, but the toxicological mechanisms involved have not been elucidated. Because it was previously demonstrated that nitrosamines and nitrosamides, representing two classes of NOC, induce distinct gene expression effects in colon cells that are particularly related to oxidative stress, we hypothesized that different radical ...

DNA mismatch binding in vitro, resistance to DNA methylation damage, and spontaneous mutation rates were examined in human colorectal adenocarcinoma cell lines. Of 11 cell lines, 3 (DLD1, HCT15, and LoVo) were defective in mismatch binding. All three lines had a mutator phenotype. These properties indicate that DLD1 and HCT15 may, like LoVo, carry mutations in the mismatch recognition protein h...

The cytotoxicities of a number of antineoplastic agents to oxygenated and hypoxic EMT6 mouse mammary tumor cells in culture were examined. Based on the relative sensitivities of cells under aerobic and hypoxic conditions, drugs were placed into three categories. Drugs that were preferentially toxic to cells under oxygenated conditions were classified as type 1 agents; this group includes bleomy...

SUMMARY The macromolecular binding of radioactivity from 1-(2-chiorethyl)-3-cyclohexyl-1-nitrosourea, labeled with ‘@ C in either the cyclohexyl moiety or the ethylene residue, was studied in the L1210 leukemia-bearing mice, in a suspension of Ll2lO leukemia cells, and during in vitro incubation with isolated nucleic acids and proteins. In all three systems, radioactivity from @ C-labeled 1-(...

A search of the literature using National Library of Medicine databases and individual cancer journal articles yielded over 500 compounds with published chemopreventive activity in animals. From these, an initial 16 agents or agent combinations have been evaluated in the following animal tumor models: mouse skin papillomas/carcinomas induced by 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylp...

Congenital diaphragmatic hernia and other congenital diaphragmatic defects are associated with significant mortality and morbidity in neonates; however, the molecular basis of these developmental anomalies is unknown. In an analysis of E18.5 embryos derived from mice treated with N-ethyl-N-nitrosourea, we identified a mutation that causes pulmonary hypoplasia and abnormal diaphragmatic developm...