نتایج جستجو برای: nitroimidazole

تعداد نتایج: 662  

Journal: :The Journal of antimicrobial chemotherapy 2004
Raúl Argüello-García Maricela Cruz-Soto Lydia Romero-Montoya Guadalupe Ortega-Pierres

OBJECTIVES We analysed, in a cell-by-cell study, the in vitro susceptibility of Giardia duodenalis strains, including Mexican isolates and their clones to 5-nitroimidazoles and benzimidazoles. METHODS Fluorogenic dye staining (FDA-PI) and cell morphology (CM) assays, two fast and direct techniques, replaced the indirect 'gold standard' method (subculture in liquid medium) in the evaluation of...

2008
Andrew M. Thompson Adrian Blaser Robert F. Anderson Sujata S. Shinde Scott G. Franzblau Zhenkun Ma William A. Denny Brian D. Palmer

The nitroimidazooxazine S-1 (PA-824) is a new class of bioreductive drug for tuberculosis. A series of related bicyclic nitroheterocycles was synthesized, designed to have a wide range of one-electron reduction potentials E(1) (from -570 to -338 mV, compared with -534 mV for S-1). The observed E(1) values closely correlated with the σm values of the heteroatom at the 4/8-position of the adjacen...

Journal: :Turkiye parazitolojii dergisi 2009
Hatice Ertabaklar Bijen Kivçak Tuba Mert Seray Ozensoy Töz

Trichomonas vaginalis (T. vaginalis) is a flagellated protozoan commonly causing sexually transmitted disease. T. vaginalis infections are treated with a 5-nitroimidazole derivate. However, drug resistance has been known to occur for a long time and new alternatives are under investigation. Arbutus unedo is a wild plant mainly growing in maquis and rocky places of the seaboard in Southern Europ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2015
Jasdeep K Saggar Ian F Tannock

PURPOSE Chemotherapy targets rapidly proliferating tumor cells, but spares slowly proliferating hypoxic cells. We hypothesized that nutrition of hypoxic cells would improve in intervals between chemotherapy, and that hypoxic cells destined to die without treatment would survive and proliferate. EXPERIMENTAL DESIGN We therefore evaluated repopulation and reoxygenation following chemotherapy, a...

Journal: :Antimicrobial agents and chemotherapy 2015
A M Upton S Cho T J Yang Y Kim Y Wang Y Lu B Wang J Xu K Mdluli Z Ma S G Franzblau

Nitroimidazoles are a promising new class of antitubercular agents. The nitroimidazo-oxazole delamanid (OPC-67683, Deltyba) is in phase III trials for the treatment of multidrug-resistant tuberculosis, while the nitroimidazo-oxazine PA-824 is entering phase III for drug-sensitive and drug-resistant tuberculosis. TBA-354 (SN31354[(S)-2-nitro-6-((6-(4-trifluoromethoxy)phenyl)pyridine-3-yl)methoxy...

2012
Javier P Gisbert Xavier Calvet

BACKGROUND Traditional standard triple therapy for Helicobacter pylori (H. pylori) infection (proton pump inhibitor-clarithromycin-amoxicillin) can easily be converted to non-bismuth quadruple (concomitant) therapy by the addition of a nitroimidazole twice daily. AIM To critically review evidence on the role of non-bismuth quadruple therapy (proton pump inhibitor-clarithromycin-amoxicillin-ni...

2015
Jyh-Ming Liou Chi-Yang Chang Mei-Jyh Chen Chieh-Chang Chen Yu-Jen Fang Ji-Yuh Lee Jeng-Yih Wu Jiing-Chyuan Luo Tai-Cherng Liou Wen-Hsiung Chang Cheng-Hao Tseng Chun-Ying Wu Tsung-Hua Yang Chun-Chao Chang Hsiu‐Po Wang Bor-Shyang Sheu Jaw-Town Lin Ming-Jong Bair Ming-Shiang Wu

OBJECTIVE The Taiwan Government issued a policy to restrict antimicrobial usage since 2001. We aimed to assess the changes in the antibiotic consumption and the primary resistance of H. pylori after this policy and the impact of virulence factors on resistance. METHODS The defined daily dose (DDD) of antibiotics was analyzed using the Taiwan National Health Insurance (NHI) research database. ...

Journal: :BMC Gastroenterology 2001
Ian LP Beales

BACKGROUND Many Helicobacter pylori eradication regimens have been described. There are little data reporting their efficacy or integration in routine clinical practice. The overall results of eradication therapy in a cohort of patients are described and an algorithm for management outlined. METHODS 469 patients receiving eradication therapy in routine clinical practice were evaluated. The su...

Journal: :Biochemical Society transactions 1984
A Y Lu P G Wislocki E S Bagan R W Wang J S Walsh G T Miwa

bromophenol is formed from bromobenzene-3,4-oxide nonenzymically, the decrease in p-bromophenol formation may be used as an indirect measure of the decrease in the extracellular concentration of bromobenzene-3,4-oxide in the presence of the transferase. From these data, we found that only negligible amounts of the epoxide re-entered the cells; that is, kZ1 was negligible and that about 59% of t...

Journal: :The British journal of venereal diseases 1980
J G Meingassner

The selectively toxic effect of nitroimidazole drugs towards anaerobic bacteria and protozoa depends on a number of factors. The killing action of such drugs as metronidazole requires the reduction of the nitro group, a process which influences the rate of entry of the drug into the susceptible cell and which is determined by mechanisms involving ferredoxin-linked (or the equivalent) reactions ...

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