Background: UTI is one of the commonest domiciliary and nosocomial bacterial infection, especially affecting the females. Nowadays antibiotic resistance among uropathogens is an emerging problem in treatment of UTI. Periodic assessment of antimicrobial susceptibility among the microorganisms will be fruitful in treating UTI. Aims: To study and assess the sensitivity/resistance pattern among E.c...

264 The Journal of Clinical Pharmacology T HE effects of dosage form variables on therapeutic efficacy and/or bioavailability of drugs are well documented.m Usually, these effects will be manifest principally in differences in rate of absorption and/or differences in efficiency of absorption. Since a formulation which releases a drug slowly over an extended time could have the same bioavailabil...

Results: The rate of bacteriuria was found statistically higher in 50 patients under trimethoprim/sulphamethoxazole and 17 under nitrofurantoin prophylaxis after the urodynamics (P < 0.05) compared to pre-urodynamics. According to our results, the most frequently bacteria detected before urodynamic testing was E. coli (in 25 patients, 3 of them ESBL + strains) as it was the same as post-urodyna...

The study aimed to investigate the bacterial etiology of endometritis and in vitro antibiotic sensitivity of the isolates in dromedary camels admitted to a clinic. Uterine swabs were collected from 45 animals diagnosed as suffering from endometritis out of 95 infertile female camels. The samples were subjected to bacteriological isolation and identification. All the isolates were tested for in-...

The high-performance liquid-chromatographic method described here for the quantitative analysis for nitrofurantoin in urine and plasma involves direct analysis of urine samples and analysis of plasma samples after protein precipitation by methanol. The assay, which requires only 0.2 ml of biological fluid and shows a linear relationship in the range 0.02 to 200 mg/liter, can be performed in 9 m...

In 1956, West and Zimmerman reported a 'first case' of haemolytic anaemia, apparently caused by the use of nitrofurantoin (Furadantin). Since then, no further reports of this untoward effect of the drug have appeared in the literature. Recently a case of acute pyelonephritis treated with Furadantin, observed in the Paediatric Department of the Poriah Government Hospital in Tiberias, developed s...

Nitrofurantoin is a synthetic antibacterial drug derived from furan by the addition of a nitro group and a side chain containing hydantoin (Fig. 1). It has a bacteriostatic, and, in higher concentration, a bactericidal, action on a wide range of Grampositive and Gram-negative organisms. It is widely used in the treatment of urinary tract infections. Common complications caused by the drug are a...