Cutaneous absorption of nitroglycerin is a well-documented phenomenon which may have unique advantages for the sustained prophylaxis of angina pectoris. Therefore, we have examined the effects of nitroglycerin ointment and placebo on exercise capacity in 14 patients with angina pectoris. Nitroglycerin ointment produced a significant increase in exercise capacity which persisted for at least thr...

Cutaneous absorption of nitroglycerin is a well-documented phenomenon which may have unique advantages for the sustained prophylaxis of angina pectoris. Therefore, we have examined the effects of nitroglycerin ointment and placebo on exercise capacity in 14 patients with angina pectoris. Nitroglycerin ointment produced a significant increase in exercise capacity which persisted for at least thr...

Present study was undertaken as an attempt to study the effect of pollutants on biological responses of Sphagnum growing at Kainchi, Kumaon hills (Uttranchal). Sphagnum plants of almost identical size, collected from the marked sites of Kainchi in different seasons viz., monsoon, winter, summer and again in monsoon, were analysed for chlorophyll, protein, shoot length and nitrate reductase and ...

The impact of zinc on the reductive dissolution of hematite by the dissimilatory metal-reducing bacterium Shewanella putrefaciens CN32 was studied in batch culture mode. Experiments were conducted with hematite (2.0 g L 1) in 10 mM PIPES (pH 6.8) and H2 as the electron donor under nongrowth conditions (108 cell mL 1), spiked with zinc (0 to 0.23 mM), and incubated for 5 days. Experiments were a...

We sought to examine mechanisms responsible for increased vasoconstriction that occurs during development of nitroglycerin tolerance. Rabbits were treated for 3 days with nitroglycerin patches (0.4 mg/hr), and their aortic segments were studied in organ chambers. This treatment resulted in attenuated in vitro relaxations to nitroglycerin and increased contractile sensitivity to angiotensin II, ...

OBJECTIVES We set out to determine the effect of sustained treatment with nitroglycerin (GTN) on neural modulation of heart rate in humans. BACKGROUND Acutely, exogenous and endogenous nitric oxide reduces sympathetic, while increasing vagal, outflow. An animal study showed loss of these effects during nitrate tolerance. METHODS A total of 29 healthy men (age range, 18 to 32 years) received...

Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and that its inhibition accounts for mechanism-based tolerance in vitro. The extent to which ALDH-2 contributes to GTN tolerance (impaired relaxation to GTN) and cross-tolerance (impaired endothelium-dependent relaxat...