The plasma pharmacokinetic study of abacavir sulphate was investigated after oral administration free solution, freshly prepared niosomal and proniosomal dispersions. loaded niosome vesicles were by the thin-film hydration method proniosomes slurry using tween 60 as surfactant cholesterol a membrane stabilizer dicetyl phosphate negative charge inducer. Maltodextrin used carrier in proniosome fo...

In this review article, liposome a novel drug delivery has been discussed, which is one among the various system used to target particular tissue. As structural similarity between lipid bilayer and cell membrane, can easily penetrate produce an effective of such that free would not able penetrate. Some other systems include niosomes, microparticles, resealed erythrocytes, pharmacosomes, etc. Th...

Abstract Background Melittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty niosome had been optimized anticancer effect assessed in vitro on 4T1 SKBR3 breast cell lines vivo BALB/C inbred mice. "Thin-layer hydration method" was used preparing niosomes; different niosomal formulations meli...

The history of using vesicular systems for drug delivery to and through skin started nearly three decades ago with a study utilising phospholipid liposomes to improve skin deposition and reduce systemic effects of triamcinolone acetonide. Subsequently, many researchers evaluated liposomes with respect to skin delivery, with the majority of them recording localised effects and relatively few stu...

The chronic glaucoma with open angle is the second leading cause of blindness in the world. Ophthalmic drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical scientist. Poor bioavailability of drugs from ocular dosage form is mainly due to the tear production, non-productive absorption, transient residence time, and impermeability of corneal epithelium....

Most of the cytotoxic chemotherapeutic agents have poor aqueous solubility. These molecules are associated with poor physicochemical and biopharmaceutical properties, which makes the formulation difficult. An important approach in this regard is the use of combination of cyclodextrin and nanotechnology in delivery system. This paper provides an overview of limitations associated with anticancer...