niosomes are non-ionic surfactant vesicles that have potential applications in the delivery of hydrophilic and hydrophobic drugs. the topical form of n-acetyl glucosamine (nag) recently has been considered in the treatment of hyperpigmentation disorders due to its inhibitory effect on thyrosinase enzymes in melanocytes. to improve nag penetration into the skin we formulated the drug in niosomes...

The present study was conducted to investigate the performance of different size reduction techniques including probe sonication, extrusion, and high pressure homogenization for nanosizing of niosomes. Also, the effects of cholesterol content and surfactant type on the size and poly dispersity index (PDI) of the formulations were evaluated. Various niosomal formulations composed of Brij 72, Spa...

Gugulipid is an ethyl acetate extract of guggul resin, obtained from Commiphora wightii (Fam.: Burseraceae) and is official in Indian Pharmacopoeia (1). The active constituent of gugulipid is guggulsterone (4,17(20)-pregnadiene3,16-dione) (2), which is present in a concentration of 4.0ñ6.0%.The guggulsterone is present in guggulipid in the form of stereoisomers E-guggulsterone and Z-guggulstero...

Abstract Background Melittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty niosome had been optimized anticancer effect assessed in vitro on 4T1 SKBR3 breast cell lines vivo BALB/C inbred mice. "Thin-layer hydration method" was used preparing niosomes; different niosomal formulations meli...

Design and development of novel drug delivery system (NDDS) has two prerequisites. First, it should deliver the drug in accordance with a predetermined rate and second it should release therapeutically effective amount of drug at the site of action. Conventional dosage forms are unable to meet these requisites. Niosomes are essentially non-ionic surfactant-based multilamellar or unilamellar ves...