Analysis of a series of diffraction data sets measured from four native as well as four nicotinic acid-soaked crystals of trypsin at 100 K shows a high variability in radiation-sensitivity among individual crystals for both nicotinic acid-soaked and native crystals. The level of radiation-sensitivity and the extent of its variability is statistically indistinguishable between the two conditions...

Nicotinic acid is widely used in the food, pharmaceutical and biochemical industries. Compared to chemical methods, enzymatic conversion of 3-cyanopyridine is an advantageous alternative for the production of nicotinic acid and nicotinamide. The separation of the product is complicated, owing to its high dilution rate in fermentation broth and high cost. Reactive liquid-liquid extraction by a s...

Purpose: We sought to identify predictive biomarkers for a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Experimental Design:We use a NAMPT inhibitor, GNE-617, to evaluate nicotinic acid rescue status in a panel ofmore than 400 cancer cell lines.Using correlative analysis andRNA interference (RNAi), we identify a specific biomarker for nicotinic acid rescue status. We next det...

The effects of ethanolic and aqueous extracts of Rheum ribs L. (RR) of the family polygonaceae was studied on serum cholesterol concentration in rabbits. To induce hypercholesterolemia, 0.5 g/kg/day of pure cholesterol powder was given orally to each rabbit for two weeks then cholesterol was halved and each group of animals was treated with a different regimen for another two weeks. Both t...

Nicotinic acid is widely used in the food, pharmaceutical and biochemical industries. Fermentation technology for the production of nicotinic acid in particular has been known for more than a century and acid have been produced in aqueous solutions. Reactive liquid-liquid extraction for the recovery of the organic acids by a suitable extractant has been found to be a promising alternative to th...