We report the case of a 63-year-old man with severe hypercalcemia, acute kidney injury, and concomitant diagnosis germinal center diffuse large B-cell lymphoma (nHL). Hypercalcemia is common finding in patients cancer. Multiple mechanisms can lead to hypercalcemia malignancy, different malignancies are often associated specific mechanism hypercalcemia. Parathyroid hormone-related protein (PTHrP...

Aggressive primary mediastinal non-Hodgkin's lymphomas (NHL) represent a particular entity among intrathoracic neoplasms. Twenty-nine patients with primary mediastinal aggressive NHL diagnosed and treated in the author's institution were studied. According to the Revised European-American Lymphoma (REAL) classification, there were 15 diffuse large B-cell, eight T-lymphoblastic, four anaplastic,...

Mantle cell lymphoma (MCL) comprises 3-10% of NHL, with survival times ranging from 3 and 5 years. Indolent lymphomas represent approximately 30% of all NHLs with patient survival largely dependent on validated prognostic scores. High response rates are typically achieved in these patients with current first-line chemoimmunotherapy. However, most patients will eventually relapse and become chem...

Introduction: While combination therapy is the standard of care for relapsed/ refractory non-Hodgkin lymphoma (RR-NHL), choice combinations an individual patient empirical, and response rates remain poor. Here we explore use a hybrid experimental/analytic method termed Quadratic Phenotypic Optimization Platform (QPOP), prediction optimal drug from limited clinical material. This high-throughput...

OBJECTIVE To observe the frequency of histological subtypes of childhood non-Hodgkin's lymphoma and its immunohistochemical profile. SETTING All cases of non-Hodgkin's lymphoma diagnosed in children (< 15 years) in the section of histopathology at the Aga Khan University Hospital Karachi during the period of three years. METHODS These consecutive cases were evaluated on H&E stained sections...

B-cell activation biomarkers have been associated with increased risk of non-Hodgkin lymphoma (NHL) in HIV-infected populations. However, whether a similar association may exist in general populations has not been established. We conducted a case-control study within the Women's Health Initiative Observational Study cohort to measure the B-cell activation biomarkers sCD23, sCD27, sCD30, sCD44, ...

objective(s): to investigate the efficacy of interleukin 11 (il-11) towards the high dose methotrexate (hdmtx)-concurrent rat small intestinal mucositis and its impacts on the proliferation of the human t-lymphoblastic leukemia (cem) cell line. materials and methods:95 wistar rats were randomly divided into five groups, the normal control group (a), the methotrexate (mtx) control group (b), the...

background and objective: the management of apoptotic cell death has been considered as a putative therapeutic strategy for cancer treatment. in the present study we investigated the putative pro-apoptotic effect of allicin, the main garlic organosulfur component with repeatedly claimed chemopreventive potency, on the human adenocarcinoma cell line ht29 as an apoptosis resistant cell line, in v...

the cytotoxicity of the biomaterials is a key issue that should be addressed prior to pre-clinical applications. this study was designed to evaluate and compare the cytotoxixity of two forms of bioactive glasses:nanopowder:andmicropowder. human hgf1-pi53 gingival fibroblast cells were used to evaluate the cytotoxicity of 0.5, 1, 1.5, 2, 5, 10, 15 and 20 mg/ml concentrations of the two bioactive...

BACKGROUND Epidemiological evidence has suggested an association between hepatitis C virus (HCV) infection and B-cell lymphoproliferation. We studied the prevalence of HCV infection in a series of de novo B-cell non-Hodgkin's lymphoma (B-NHL) cases and correlated virological findings with clinico-histological features. PATIENTS AND METHODS One hundred fifty-seven patients with de novo B-NHL w...