BACKGROUND There is insufficient evidence to support visceral leishmaniasis (VL) treatment recommendations in Brazil and an urgent need to improve current treatments. Drug combinations may be an option. METHODS A multicenter, randomized, open label, controlled trial was conducted in five sites in Brazil to evaluate efficacy and safety of (i) amphotericin B deoxycholate (AmphoB) (1 mg/kg/day f...

Lamb waves are frequently used in nondestructive evaluation and are proposed for structural health monitoring applications. While many numerical methods to obtain dispersion curves for Lamb waves have been developed and implemented, in general they are time consuming and do not lend themselves to analyses involving the perturbation of parameters such as the small thickness and wave speed change...

Spoilage of meat has remained a serious challenge in developing countries. The objective of this study was to evaluate the beef and lamb meat quality from supermarkets and shops in summer and winter season. Beef and lamb meat were stored at 4±1 o C during 5 days and test for microbiological properties, oxidation stability, and color properties, in beef and lamb meat. Samples were collected from...

This paper reports genetic parameters for lamb survival and mortality traits on sheep farms in New Zealand. Lamb survival and mortality records were obtained from 38 flocks (103,357 lambs) from 5 yr of lambing data (2007 to 2011) and include many breeds and their crosses (predominantly Romney, Perendale, Coopworth, and Texel). A number of models were tested, all including environmental weather ...

The number of lambs sold per ewe mated in the breeding flock has a considerable impact on sheep operation profitability. This depends primarily on fertility, prolificacy (# of lambs), and lamb survival, mothering ability, milk production of the ewe and lamb growth rate. Optimal reproduction does vary by environment and management system – some sheep operations don’t want a lambing rate over 200...

Data on antifungal prophylaxis in paediatric cancer patients at high risk for invasive fungal disease (IFD) are scant. Intermittent administration of liposomal amphotericin B (LAMB) has been shown to be safe and effective in adult patients with haematological malignancies. We prospectively evaluated the safety and efficacy of prophylactic LAMB at a dosage of 2.5 mg/kg twice weekly in children a...

Chorioamnionitis increases the risk and severity of persistent pulmonary hypertension of the newborn in preterm infants. Exposure of preterm fetal lambs to intra-amniotic (IA) lipopolysaccharide (LPS) induces chorioamnionitis, causes hypertrophy of pulmonary resistance arterioles, and alters expression of pulmonary vascular growth proteins. We investigated the cardiopulmonary and systemic hemod...

Recently, Wong et al. (Wong KA, Bano A, Rigaux A, Wang B, Bharadwaj B, Schurch S, Green F, Remmers JE, and Hasan SU, J Appl Physiol 85: 849-859, 1998) demonstrated that fetal lambs that have undergone vagal denervation prenatally do not establish adequate alveolar ventilation shortly after birth. In their study, however, vagal denervation was performed prenatally and the deleterious effects of ...

Neonatal changes in plasma total and free iodothyronine levels were monitored in 18 Limousin X Romanov suckling lambs (experiment 1) and 24 Limousin X Romanov animals bottle-fed in standardized conditions (experiment 2). In the two experiments, plasma free T3 levels were closely related to total T3 levels, whereas some differences could be observed between total and free plasma T4 levels. The n...