BACKGROUND Microbial keratitis is an infectious disease of the cornea characterised by inflammation and is considered an ophthalmic emergency requiring immediate attention. While a variety of pathogenic microbes associated with microbial keratitis have been identified, a comprehensive review identifying the diversity of species has not been completed. METHODS A search of peer-reviewed publica...

How to Treat Bacterial Keratitis Bacterial keratitis in dogs is a common disease that can be aggressive and may threaten vision. The exact pathogenesis is unknown. Culture of the cornea should be done when bacterial keratitis is suspected, and many suspected or confirmed cases are treated with cefazolin and tobramycin or with ciprofloxacin alone. All of these regimens provide a broad spectrum o...

Abstract Fungal keratitis is challenging to diagnose and treat remains a significant cause of blindness worldwide. The easiest most common method drug delivery for patients with fungal eye drop administration. However, the therapeutic effect traditional drops unsatisfactory, largely due intrinsic nature ocular barriers, which limit absorption; rapid decrease in concentration caused by tears; si...

objective(s): occlusal trauma is one of the most common forms of oral biting dysfunction. long-term occlusal trauma could weaken the stomatognathic system; especially damage one’s masticatory muscle. through using the rat model, this study investigated the trophic effect of ciliary neurotrophic factor (cntf) on injured masseter muscle. materials and methods: male wistar rats (n=36) were randoml...

PURPOSE To compare a 44-mer pigment epithelial-derived factor (PEDF) peptide with neurotrophic activity, and a 34-mer PEDF with antiangiogenic properties in association with docosahexaenoic acid (DHA) in corneal nerve regeneration after experimental surgery. METHODS A corneal stromal dissection was performed in rabbits. Treatment groups received topical 44-mer, 34-mer, or full PEDF plus DHA. ...

Purpose To limit corneal damage and potential loss of vision, bacterial keratitis must be treated aggressively. Innovation in antimicrobials is required due to the need for empirical treatment and the rapid emergence of bacterial resistance. Designed host defense peptides (dHDPs) are synthetic analogues of naturally occurring HDPs, which provide defense against invading pathogens. This study in...

INTRODUCTION Corneal infection is the most common cause of profound ocular morbidity leading to blindness worldwide. Corneal infection in children is difficult to diagnose and treat, as they are unwilling and sometimes unable to cooperate during active management. This study analyses the prevalence, microbiology, demography, therapeutic and visual outcome of infectious microbial keratitis in th...

Bacterial keratitis is a serious ocular infection that can cause severe visual loss if treatment is not initiated at an early stage. It is most commonly caused by Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumoniae, or Serratia species. Depending on the invading organism, bacterial keratitis can progress rapidly, leading to corneal destruction and potential blindness. Common...

Infectious keratitis is the most common condition of corneal diseases in which a pathogen grows cornea leading to inflammation and destruction tissues. medical emergency for rapid accurate diagnosis needed ensure prompt precise treatment halt disease progression limit extent damage; otherwise, it may develop sight-threatening even eye-globe-threatening condition. In this paper, we propose seque...