Neuroprotective agents may exert their effect by reducing cerebral oxygen demand (CMRO2), increasing cerebral oxygen delivery, or by altering ongoing pathological processes. Barbiturates provide neuroprotection by reducing the CMRO2 necessary for synaptic transmission while leaving the component necessary for cellular metabolism intact. Isoflurane may exert a neuroprotective effect by a similar...

Cardiovascular and renal diseases constitute two pathophysiological contexts of progressive fatal recognitions worldwide as priorities in terms health its entirety. Erythropoietin is a glycoprotein hormone which produces red blood cells, carry oxygen the blood. The objective was to know most prevalent modifiable risk factors found arterial hypertension, since this disease third cause death worl...

Abstract Stroke causes death and disability globally but no neuroprotectant is approved for post-stroke neuronal injury. Neuroprotective compounds can be identified using oxygen glucose deprivation (OGD) of cells as an in vitro stroke model. Nerve growth factor (NGF)-differentiated PC12 pheochromocytoma are frequently used. However, investigators often find their clonal variant undifferentiable...