Residual neuromuscular blockade in the postoperative period contributes to significant morbidity and possibly mortality. The incidence of residual neuromuscular blockade has been shown to decrease with the use of neuromuscular monitoring and short acting neuromuscular blocking drugs. Because of marked variation in patient's sensitivity to neuromuscular blockade, the neuromuscular function of th...

neuromuscular disorders (nmds) include a broad range of diseases affecting muscles, nerves and neuromuscular junctions. approximately 761 different disorders occur in this group which is subdivided into 16 different subgroups with 406 known genes. nmds are genetically and clinically heterogeneous conditions. the advent of next generation sequencing (ngs) approaches has accelerated the pace of d...

channelopathies are disturbances of the cellular membrane channels function. ion channels are actually membrane-bound proteins that perform key functions in virtually all human cells. these channels play pivotal role in the function of excitable tissues such as muscle and nerve. so channelopathies are diverse clinical entities involving many organs and systems (i.e., endocrine, respiratory, gas...

the ventilatory pump upon which the act of breathing depends. In many neuromuscular disorders, muscle weakness involves the respiratory muscles to an equal or even greater extent than other skeletal muscles. The degree of limb muscle weakness cannot be used as a reliable guide to the presence of respiratory muscle impairment since the correlation between the two may be quite poor.1,2 Respirator...

PURPOSE The aim of this study was to test the hypotheses that prolonged mental exertion (i) reduces maximal muscle activation and (ii) increases the extent of central fatigue induced by subsequent endurance exercise. METHODS The neuromuscular function of the knee extensor muscles was assessed in 10 male subjects in two different conditions: (i) before and after prolonged mental exertion leadi...