Chronic exposure to manganese (Mn) produces a spectrum of cognitive and behavioral deficits associated with a neurodegenerative disorder resembling Parkinson's disease. The effects of high-dose exposure to Mn in occupational cohorts and in adult rodent models of the disease are well described but much less is known about the behavioral and neurochemical effects of Mn in the developing brain. We...

BACKGROUND AND PURPOSE To investigate experimental mechanisms of reversible cerebral dysfunction, we produced transient focal cerebral ischemia in five baboons by unilateral perfusion of internal carotid territories with platelet microemboli generated endogenously. METHODS Platelet microemboli were formed by incorporating segments of Dacron vascular graft for 1 hour as unilateral carotid arte...

We detected infection with a Bartonella species (B. henselae or B. vinsonii subsp. berkhoffii) in blood samples from six immunocompetent patients who presented with a chronic neurological or neurocognitive syndrome including seizures, ataxia, memory loss, and/or tremors. Each of these patients had substantial animal contact or recent arthropod exposure as a potential risk factor for Bartonella ...

Decreased ability to smell results from a number of medical conditions, ranging from simple congestion of the nose to serious neurological disturbances. In this chapter I provide an overview of the olfactory dysfunctions present in several major neurological disorders and discuss current theories as to their cause. In some disorders, such as Alzheimer's disease and idiopathic Parkinson's diseas...

Phenylketonuria (PKU), if not detected and treated in newborns, causes severe neurological dysfunction and cognitive and behavioral deficiencies. Despite the biochemical characterization of PKU, the molecular mechanisms underlying PKU-associated brain dysfunction remain poorly understood. The aim of this study was to gain insights into the pathogenesis of this neurological damage by analyzing p...

Most commonly, COVID-19 presents as a respiratory disease, but growing body of clinical evidence shows that neurological symptoms and complications contribute significantly to the spectrum especially in patients with severe disease. The public health impact long-term (or even life-long) consequences disease may be much greater than acute manifestations SARS-CoV-2 infection. As pandemic has evol...

STUDY DESIGN Single-center retrospective study. PURPOSE To clarify the clinical features of cervical myelopathy at the C1-2 level. OVERVIEW OF LITERATURE Methods for distinguishing the affected level based on myelomere symptoms or dysfunction of the conducting pathway were established. However, no symptoms have been identified as being specific to the C1-2 level segment. METHODS We evalua...