Neuroendocrine tumors of the breast are very rare accounting for less than 0.1% of all breast cancers and less than 1% of all neuroendocrine tumors. Focal neuroendocrine differentiation can be found in different histologic types of breast carcinoma including in situ and invasive ductal or invasive lobular. However, primary neuroendocrine carcinoma of the breast requires the expression of neuroe...

paragangliomas are neoplasms of neural crest origin. in the head and neck, they uncommonly involve the larynx. the distinction between paragangliomas and other neuroendocrine tumors can be difficult. precise diagnosis is important in order to optimize patient treatment. diagnosis relies mostly on histopathologic examination followed by immunohistochemistry. here we report a 77-year-old woman wi...

Neuroendocrine tumors, or more properly gastro-entero-pancreatic tumors (GEP-NETs), are cancers of the interface between the endocrine (hormonal) system and the nervous system. A neuroendocrine tumor begins in the hormone-producing cells of the body’s neuroendocrine system, which is made up of cells that are a cross between traditional endocrine cells (or hormone-producing cells) and nerve cell...

OBJECTIVES To describe the biological behavior and surgical management of ampullary neuroendocrine tumors in 7 patients. DESIGN Case series and literature review. SETTING University hospital. PATIENTS Seven patients with ampullary neuroendocrine tumors. MAIN OUTCOME MEASURES Clinical presentation, pathologic findings, and survival. RESULTS The patients presented with jaundice (3 patie...

The purpose of the study was to evaluate changes in general self-efficacy, health related quality of life (HRQoL), and stress among patients with neuroendocrine tumors (NET) following a multidisciplinary educational intervention. Forty-one patients were enrolled in this exploratory pilot study. A total of 37 patients completed the full 26-week intervention based on the principles of self-effica...

Incidentally detected, sporadic, nonfunctional pancreatic neuroendocrine tumors are increasingly diagnosed on imaging studies performed for unrelated purposes. Although their resection is usually recommended, controversy still exists regarding their optimal management, due to their highly variable and difficult to predict biologic behavior. Recently, several studies and guidelines advocated an ...

Neuroendocrine differentiation of tumor tissue has been recognized as an important prerequisite for new targeted therapies. To evaluate the suitability of colorectal cancer (CRC) tissue for these treatment approaches and to find a possible link to pretherapeutic conditions of other targeted strategies, we compared neuroendocrine differentiation and KRAS/NRAS/BRAF/PIK3CA/TP53 mutational status i...

metastasis from a malignant tumor to the palatine tonsils is rare, accounting for only 0.8% of all tonsillar tumors, with only 100 cases reported in the english-language literature. various malignant lung carcinomas may metastasize to the tonsils. a few cases of tonsillar metastasis from neuroendocrine lung carcinoma have been reported. a 67-year-old female underwent a right tonsillectomy becau...

Neoplastic lesions that demonstrate neuroendocrine features are rare. However, esophageal tumors containing both adenocarcinomatous and neuroendocrine components are exceedingly rare. Mixed adenoneuroendocrine carcinomas (MANECs) are gastrointestinal tumors with both adenocarcinomatous and neuroendocrine differentiation. They have a tendency for early metastases but clinically manifest relative...