An interesting example of extradermal deposition of melanin in vertebrates, notably in mammals, is splenic melanosis. In particular, if the phenomenon of splenic melanosis is correlated with hair or skin pigmentation, it must reflect the amount and perhaps the quality of pigment produced in hair follicle melanocytes. The present paper is our first study on splenic pigmentation in mice of phenot...

Esophageal melanosis which is characterized by melanocytic proliferation in the squamous epithelium of the esophagus and melanin accumulatin of esophageal mucosa (EM) is a rare disease of the digestive system. Although esophageal melanosis is considered to be a benign disease, its etiology is not cleared and has been reported to be the precursor lesion of esophageal primary melanomas. In this r...

Case report. A 12-year-old boy with multiple nevi presented with 6 months of polydipsia ( 4 L/day), polyuria, and a 40-pound weight loss that progressed over weeks to intractable headache and vomiting. The patient subsequently developed ataxia, complex partial seizures, and encephalopathy. Medical history was significant for numerous (40 to 50) benign congenital nevi ranging in diameter from 1 ...

Benign melanotic lesions of the vagina are uncommon and only a few cases have been reported in the literature. A 34-year-old woman was referred because of a Vaginal Intraepithelial Neoplasia 1 biopsy result. On the gynecological examination, two different hyperpigmented areas were noted in the vagina. The colposcopic visualization of the cervix and vagina found an aceto-white lesion at the righ...

Introduction: Bladder melanosis is an extremely rare condition first reported in 1986 and refers to abnormal deposits of melanin in the urothelial bladder cells. Typically, it is considered a benign condition, but it has also been described associated with urothelial carcinoma and melanoma. Its diagnosis may be difficult for most urologists because of its rarity. Case Report: We present the cas...

BACKGROUND Vulvar melanosis is a benign pigmented lesion that may clinically mimic melanoma. Whereas the dermoscopic features of other pigmented skin lesions have been extensively described, little is known about vulvar melanosis. OBSERVATIONS A retrospective dermoscopic study was conducted on 87 lesions with histopathologically proved melanosis. We describe and define, for the first time to ...

n engl j med 368;24 nejm.org june 13, 2013 2303 A 50-year-old woman underwent colonoscopy for rectal bleeding. Her entire colon appeared dark brown and black, a finding consistent with the diagnosis of melanosis coli (Panel A). Random biopsy specimens from the descending colon revealed sheets and clusters of macrophages laden with brownish pigment in the lamina propria (Panel B, arrow). A tiny,...

Sir,?I am referring to a paper 'on p. 172 of the Indian Medical Gazette, April 1944, on 'Syphilitic melanoderma' where ycm state that in Becher and Obermayer no mention is made of syphilis as a cause of melanosis. In my book ' Histologie der Hautkrankheiten' Springer Verlag, Berlin 1925, Vol. I, p. 517, I do mention it and refer to Fourrier and to Unna as describing it as a rare type of the dis...