نتایج جستجو برای: neopterin
تعداد نتایج: 993 فیلتر نتایج به سال:
INTRODUCTION AND OBJECTIVES Activation of the cell-mediated immune system plays an important role in atherogenesis and in triggering the development of acute coronary syndrome. Neopterin, a biomarker of cell-mediated immune system activity, is also a well-known biomarker of coronary artery disease. It is known that the occurrence of coronary heart disease events is not distributed evenly throug...
QuantiFERON-TB-Gold (QFT-G) conversion is frequently observed in rheumatoid arthritis (RA) patients receiving biologic therapy. However, there have not been any known biomarkers available for detecting tuberculosis (TB) in QFT-G converters. We aimed to evaluate clinical utility of cytokines/chemokines for detecting TB in patients with QFT-G conversion. Among a total of 227 RA patients who under...
BACKGROUND Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. METHODS A nested case-control study was conducted withi...
BACKGROUND We aimed to measure the levels of inflammatory markers and neopterin in obese and non-obese patients with PCOS by using 2 separate control groups with matching body mass index (BMI). MATERIAL AND METHODS A total of 60 women of reproductive age with (n=30) and without (n=30) PCOS were included in this study. Based on their BMI, patients with PCOS were divided into 2 groups as obese ...
This study was designed to investigate the ability of bronchoalveolar and blood mononuclear cells to produce inflammatory mediators in vitro in pulmonary sarcoidosis. Seventeen patients with pulmonary sarcoidosis (stage I n = 8; stage II/III n = 9) and 10 normal controls were investigated. Bronchoalveolar and peripheral blood mononuclear cells were cultured in serum-free medium, without stimula...
BACKGROUND Chronic immune activation is a hallmark of HIV infection and has been associated with disease progression. Assessment of soluble biomarkers indicating immune activation provide clues into pathogenesis and hold promise for the development of point-of-care monitoring of HIV in resource-poor-settings. Their evaluation in cohort resources is therefore needed to further their development ...
Objective: Liver transplantation using a living donor (LDLT) is currently the most popular method used in worldwide. Appropriate biomarkers that predict graft status should be to detect early post-transplant complications may lead rejection reaction. Material and Method: The study involved total of 44 liver recipients donors, from whom preoperative blood samples were taken immunoassay spectroph...
Recently, Means and Krantz showed that the inhibition of erythroid colony-forming units caused by interferon-y (IFN-y) can be corrected invitro by recombinant human erythropoietin (EPO).' In vivo, the pathogenetic mechanism of the anemia of chronic disease (ACD) is not yet understood. Because this symptom is very common, many attempts have been made to explore the factors involved and to establ...
The aim of this study was to assess neopterin, a marker of interferon gamma (IFN-gamma) induced macrophage activity, as a possible surrogate marker of inflammation in patients with multiple sclerosis. Urinary neopterin to creatinine ratios (UNCRs) were measured daily in 10 primary progressive (PP). 10 relapsing remitting (RR) and 11 secondary progressive (SP) patients with multiple sclerosis, a...
Little is known about the dynamic characteristics of stress system activity during "life as it is lived". Using as representative a study design as possible, this investigation sought to gain insights into this area. A healthy 25-year-old woman collected her entire urine over a period of 63 days in 12-h intervals (126 measurements) to determine cortisol and neopterin (immune activation marker) ...
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