There remainsmuch controversy over the risks and benefits of statins for primary prevention. Besides the risks of muscle aches, diabetes, and cognitive dysfunction, I have observed over the years that for many patients, statins provide a false reassurance, as people seem to believe that statins can compensate for poor dietary choices and a sedentary life. In an elegantly performed analysis of N...

IT HAS BEEN a long-standing observation that overnutrition during the early lifetime can have a permanent influence on the feeding behavior and body weight gain of the adult individual. The maintenance of energy balance, which is the resultant of energy intake and expenditure, is controlled by a complex network of neurohumoral factors (2, 5, 10). Among those, neuropeptide Y (NPY), a 36-amino ac...

To the Editor: Recently, Law et al1 reported that increased weight gain during early childhood (1 to 5 years) but not during infancy (birth to 1 year) is associated with later systolic blood pressure. From the latter, they concluded that “. . . none of the evidence so far indicates that promotion of infant growth increases cardiovascular risk.”1 In our opinion, this conclusion is not only incor...

AIMS Fasting plasma glucose (FPG) concentration measured at the first prenatal visit is a predictor of gestational diabetes mellitus (GDM); however, whether this test is indicative of fetal growth has not been clarified. Thus, the purpose of this study was to determine whether birth weight and birth length were related to FPG levels at the first prenatal visit. MATERIALS AND METHODS Research ...

BACKGROUND Maternal overweight and obesity are risk factors for stillbirth and infant mortality. Whether temporal changes in maternal weight affect these risks is not clear. We aimed to assess whether change of BMI between first and second pregnancies affects risks of stillbirth and infant mortality in the second-born offspring. METHODS In a Swedish population-based cohort of women who gave b...

The key findings of this multi-centre prospective cohort study were that neonates born to mothers treated for Gestational diabetes mellitus (GDM) (by lifestyle or medication, e.g. insulin metformin) had high rates macrosomia but similar adiposity those with normal glucose tolerance. In contrast, untreated who overweight and a tolerance increased adiposity. Increased gestational weight gain was ...