Several factors are conspiring to focus attention on neonatal immunology. First, the dogma that neonatal exposure to antigen results in tolerance rather than immunity has been challenged. Second, there is a clinical imperative; the development of effective neonatal vaccines is likely to be extremely important in reducing infant morbidity and mortality, and the successful use of cord blood stem ...

Objective To compare perinatal and neonatal outcomes of dichorionic (DC) and monochorionic (MC) with trichorionic (TC) triplet gestations. Methods A retrospective cohort study of DC + MC versus TC triplet gestations delivered at a tertiary care hospital from 2009 to 2015. The results include 42 sets of triplets (TC, n = 26; DC + MC, n = 16). Maternal demographics and pregnancy data were compare...

OBJECTIVE To assess the effect of cesarean delivery on neonatal and maternal morbidity and mortality and their associated costs for two populations of women presenting with genital herpes lesions at delivery: those with and those without a history of genital herpes. DATA SOURCES MEDLINE (search for herpes simplex virus and neonatal, cesarean, and mortality) and recognized experts. DATA EXTR...

Neonatal herpes simplex virus (HSV) infection is a severe disease with high mortality and morbidity. To investigate the pathogenesis of neonatal HSV infection, we examined inflammatory responses and markers of apoptosis in patients with neonatal HSV infection. Concentrations of inflammatory cytokines and markers of apoptosis were significantly higher in patients with disseminated HSV infection ...

Low Birth Weight (LBW) is one of the public health problems. It becomes single risk factor for early neonatal mortality and morbidity. The high number LBW cases affects baby’s in future, including infants’ slow growth, impaired cognitive development, susceptibility to diseases, such as disorders respiratory, cardiovascular, gastrointestinal, kidney systems. also causes increased morbidity morta...

Infectious disease is an important cause of morbidity and mortality in the neonatal foal with approximately 8% of foals affected by some form of infectious complication in the first 30 days of life in one recent study. Early recognition and treatment of infectious complications in the neonatal period is important to maximise outcome. The purposes of this article are to review antimicrobial sele...

Neonatal pneumopericardium (PPC) is a rare form of neonatal air leak syndrome with high morbidity and mortality. Air leak syndrome in the newborn is usually associated with active resuscitation, respiratory distress syndrome, meconium aspiration syndrome, mechanical ventilation, or trauma associated with labour. Neonatal PPC can be associated with other air leak syndromes such as pneumomediasti...

OBJECTIVE The purpose of this study was to compare maternal characteristics and neonatal morbidity and mortality rates that are associated with early-onset neonatal sepsis that is caused by group B Streptococcus and Escherichia coli. STUDY DESIGN This was a retrospective review of newborn infants with a positive blood culture (and/or cerebrospinal fluid) that was positive for either E coli or...

BACKGROUND Despite widespread use of neonatal hospital discharge data, there are few published reports on the accuracy of population health data with neonatal diagnostic or procedure codes. The aim of this study was to assess the accuracy of using routinely collected hospital discharge data in identifying neonatal morbidity during the birth admission compared with data from a statewide audit of...

OBJECTIVE to evaluate the relationship between ductus venous (DV) and Doppler velocimetry in neonatal outcome in severe compromised preterm fetuses. METHODS the study was designed as an observational and cross-sectional study with 52 premature neonates with brain sparing effect. The criteria of neonatal severe morbidity were: severe intraventricular hemorrhage (grades 3 or 4), retinopathy of ...