among early neonatal deaths in the United Oxford Hospitals was noticed. When compared to an earlier survey in the same hospitals no change in the distribution by birthweight score of the affected infants was seen. The increased incidence of the syndrome coincided with a fall in the perinatal mortality rate. An analysis of the clinical features and pathological findings in the affected infants s...

BACKGROUND Neonatal hypothermia is widely associated with increased risks of morbidity and mortality, but remains a pervasive global problem. No studies have examined the impact of hypothermia on outcomes for preterm infants treated with CPAP for respiratory distress syndrome (RDS). METHODS This retrospective analysis assessed the impact of hypothermia on outcomes of 65 neonates diagnosed wit...

BACKGROUND Neonatal hearts are less susceptible to developing myocardial dysfunction after hypoxia and/or ischemia than adult hearts. Differences in intracellular calcium homeostasis may be responsible for reduced calcium overload of the immature myocardium leading to the observed protection against ischemia. OBJECTIVE To assess differences in baseline and post-ischemic gene expression of cal...

background : meningitis is more common during the neonatal period than other periods of life and has a prevalence of one in 1000 live births. the similarity of its clinical manifestations with other infectious diseases makes it difficult to diagnose. the aim of the current study was to determine the relationship between age, sex, clinical signs and symptoms and laboratory test results of newbor...

The use of spectrin breakdown products (SBDPs) and Tau protein levels for diagnosis and a mild hypothermia therapy for treatment of neonatal hypoxic-ischemic encephalopathy (HIE) was evaluated. One hundred and fifty infants, with HIE within 12 h after birth, participated in the study. There were 30 newborns with mild symptoms, 60 with moderate symptoms, 60 with severe symptoms, and 30 in a cont...

New Insights into the Pathophysiology and Treatment of Neonatal Hypoxic–Ischemic Encephalopathy Neonatal hypoxic–ischemic encephalopathy (HIE) is one of the leading causes of death and disability-adjusted life years (DALYs) in term infants (1, 2). This research topic presents a collection of one original article and four reviews covering translational research in HIE, including the utilization ...

Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy initiated within six hours after birth effectively prevents neurodevelopmental impairments in some but not all infants. In part, this may be related to the timing of hypoxia before relative initiation cooling. Metabolic acidosis at (suggesting acute hypoxia-ischemia) is required treatment with hypothermia. However, placental e...

Background : A low birth weight baby is a clinical and diagnostic challenge. The neonatologists are faced with numerous neonatal intensive care unit protocols. This study was designed to review the policies of management of neonatal jaundice, sepsis, anemia, hypoglycemia, jaundice and hypoxic encephalopathy in a low birth weight newborn. Methods: Care of newborns in was done in intensive care u...

AIMS To study early neonatal metabolic adaptation in a hospital population of neonates in Nepal. METHODS A cross sectional study was made of 578 neonates, 0 to 48 hours after birth, in the main maternity hospital in Kathmandu. The following clinical and nutritional variables were assessed: concentrations and age profiles of blood glucose, hydroxybutyrate, lactate, pyruvate, free fatty acids (...