Covalent modifications of histones play an important role in chromatin architecture and dynamics. In particular, histone lysine methylation is important for transcriptional control during diverse biological processes. The nuclear protein Jmjd5 (also called Kdm8) is a histone lysine demethylase that contains a JmjC domain in the C-terminal region. In this study, we have generated Jmjd5-deficient...

Platelet activation is a hallmark of severe preeclampsia, and platelet PGH synthase 1-derived (PGHS1-derived) thromboxane A(2) (TxA(2)) has been implicated in its pathogenesis. However, genetic disruption of PGHS1 delays parturition. We created hypomorphic PGHS1 (PGHS1(Neo/Neo)) mice, in which the substantial but tissue-dependent variability in the inhibition of PGHS1-derived eicosanoids achiev...

Purpose: Telecommunications comprises a vital component of information infrastructures and services, with an historically strong public interest dimension. For the best part of 30 years, the telecommunications sector in Europe has been the subject of a radical reorganisation in structural and operational terms along the lines of neo-liberalism. This article analyses the significance of the neo-...

The Salt Range, in Pakistan, preserves an insightful sedimentary record of passive margin dynamics along the NW Indian Plate during Mesozoic. This study develops provenance analyses Upper Triassic (Kingriali Formation) to Lower Jurassic (Datta siliciclastics from and Trans Indus ranges based on outcrop analysis, petrography, bulk sediment elemental geochemistry, heavy-mineral data. sandstones a...

The citrus leafminer, Phyllocnistis citrella Stainton (Lepidoptera: Gracillariidae), is a world-wide pest of citrus (Heppner 1993) described originally in India (Stainton 1856). In the USA, it was initially found in Homestead, Florida and parts of Dade, Broward and Collier counties in 1993 (Heppner 1993). Its distribution is now widespread across Florida in citrus-growing regions, and is spread...

The neo-sex chromosomes of Drosophila miranda constitute an ideal system to study the effects of recombination on patterns of genome evolution. Due to a fusion of an autosome with the Y chromosome, one homolog is transmitted clonally. Here, I compare patterns of molecular evolution of 18 protein-coding genes located on the recombining neo-X and their homologs on the nonrecombining neo-Y chromos...

Purpose – To show that the neo-pragmatist position of Richard Rorty, when combined with a sociocultural perspective, provides library and information science (LIS) with a forceful epistemological tool. Design/methodology/approach – Literature-based conceptual analysis of: historical development of pragmatism in relation to other epistemological positions; neo-pragmatism as a non-dualist, both p...

Sex chromosomes originate from pairs of autosomes that acquire controlling genes in the sex-determining cascade. Universal mechanisms apparently influence the evolution of sex chromosomes, because this chromosomal pair is characteristically heteromorphic in a broad range of organisms. To examine the pattern of initial differentiation between sex chromosomes, sequence analyses were performed on ...