The contribution of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway to intrathymic negative selection is a controversial subject with two studies suggesting a key role for TRAIL, while others demonstrated normal negative selection, in TRAIL- and TRAIL receptor-deficient mice. The basis of these discrepancies is unclear and may in part reflect differences in the negat...

Repeated attempts to show that costimulation for negative selection is controlled by a single cell surface molecule have been unsuccessful. Thus, negative selection may involve multiple cell surface molecules acting in consort. In support of this idea, we show here that at least three cell surface molecules, namely CD28, CD5, and CD43, contribute to Fas-independent negative selection of the tol...

introduction: beta thalassemias are a heterogenous group of autosomal recessive disorders, characterized by reduced or absent production of the b-globin chain by the affected allele. transplantation of allogenic hematopoietic stem cells (hsc) is a curative approach but this therapeutic option is not available to the majority of patients. transplantation of genetically corrected autologous hsc i...

Many recommender systems have only implicit user feedback. The two possible ratings are positive and negative, but only part of positive entries are observed. One-class matrix factorization (MF) is a popular approach for such scenarios by treating some missing entries as negative. Two major ways to select negative entries are by sub-sampling a set with similar size to that of observed positive ...

Ji, Zhou. Ph.D. The University of Memphis. August, 2006. Negative selection algorithms: from the thymus to V-detector. Major Professor: Dipankar Dasgupta, Ph.D. Artificial Immune Systems (AIS) is a research area of developing computational methods inspired by biological immune systems. The approach of negative selection algorithms (NSA) is one of the major models of AIS. This dissertation does ...

Two selection goals of inclusion or exclusion of calving interval (CI) in the selection goal function for Holstein cows in Iran, besides milk yield, milk fat percentage, and milk protein percentage, were studied. Four selection indices were composed of using the information on production traits, CI and / or days from calving to first insemination (DFI). The results of the predicted genetic grow...

T cell education in the thymus is critical for establishing a functional, yet self-tolerant, T cell repertoire. Negative selection is a key process in enforcing self-tolerance. There are many questions that surround the mechanism of negative selection, but it is currently held that apoptosis initiated by Bim and/or Nur77 is critical for negative selection. Recent studies, however, have question...

The negative selection algorithm is one of the oldest immuneinspired classification algorithms and was originally intended for anomaly detection tasks in computer security. After initial enthusiasm, performance problems with the algorithm lead many researchers to conclude that negative selection is not a competitive anomaly detection technique. However, in recent years, theoretical work has lea...

Nephrotic syndrome (NS) gene discovery efforts are now occurring in small kindreds and cohorts of sporadic cases. Power to identify causal variants in these groups beyond a statistical significance threshold is challenging due to small sample size and/or lack of family information. There is a need to develop novel methods to identify NS-associated variants. One way to determine putative functio...