We report the case of a 44-year-old woman who presented with vaginal bleeding. Vaginal examination and colposcopy showed a tumor on the anterior lip of the cervix. Trans-vaginal sonography revealed a thickened endometrium with accentuated vascularization. Samples from the tumor and endometrium were collected by byopsic curettage. Histopathologic examination showed atypical hyperplasia of the en...

Much has been written about the nodules of rheumatoid arthritis, which, though present in less than a quarter of the patients, ma) nevertheless be regarded as constituting an important, if not the most important, feature from the pathological point of view. Collins (1937) and others, including Parkes Weber (1943, 1944), Kersley and others (1946) have shown that the characteristic subcutaneous n...

Juvenile xanthogranuloma (JXG) is a rare histiocytic disorder that is usually benign and self-limiting. We present a case of atypical, aggressive JXG harboring a novel mitogen-activated protein kinase (MAPK) pathway mutation in the MAPK1 gene, which encodes mitogen-activated protein kinase 1 or extracellular signal-regulated 2 (ERK2). Our analysis revealed that the mutation results in constitut...

Intraocular lacrimal gland tissue is an extremely rare choristoma. A newborn girl was seen with a fleshy, vascular tumor arising from the peripheral iris and the anterior chamber angle. The tumor was treated with topical steroids on suspicion of a juvenile xanthogranuloma; later, it grew slightly and a secondary glaucoma developed. Histopathological examination of the resected tumor showed lacr...

The incidence and structure of subcutaneous nodules in rheumatic fever and rheumatoid arthritis have been the subject of research for many years. In 1937 Collins published a paper on the subcutaneous nodule in rheumatoid arthritis, and in 1939 he reviewed in these Annals some of the work on the pathology of rheumatic fever and rheumatoid arthritis. He mentions the basic pattern of tissue change...

In the course of studies8 on the development of transplants of tumor 15091a4 in susceptible and resistant strains of mice, it was noted that after a preliminary period of growth in certain animals the grafts regressed completely. This phenomenon of regression of the transplanted mouse tumor is well known. (See Woglom10 for a review of early work on this subject.) Histologically, necrosis of the...

Solitary juvenile xanthogranuloma (JXG) in the spinal column is extremely rare. Here, we report and characterize the case of xanthogranuloma of the upper cervical spine. A 18-year-old male presented with neck pain for 3 months, along with progressive quadriparesis and sensory loss of 2 months duration with urinary retention. Motor examination revealed spastic quadriparesis with power of 2/5 in ...