In the course of studies8 on the development of transplants of tumor 15091a4 in susceptible and resistant strains of mice, it was noted that after a preliminary period of growth in certain animals the grafts regressed completely. This phenomenon of regression of the transplanted mouse tumor is well known. (See Woglom10 for a review of early work on this subject.) Histologically, necrosis of the...

Annular elastolytic giant cell granuloma is a condition characterized histologically by damaged elastic fibers associated with preponderance of giant cells along with absence of necrobiosis, lipid, mucin, and pallisading granuloma. It usually occurs on sun-damaged skin and hence the previous name actinic granuloma. A similar process occurs on the conjunctiva. Over the past three decades only fo...

The distribution of acid phosphatase in mouse mammary tumors was studied by light and electron microscopy technics. Following X-irradiation, the concentration and size of the lysosomes in the tumor cells were increased, and final reaction products of the histochemical test were detected free in the cytoplasm and in intercellular spaces. Areas of focal degradation and necrobiosis appeared associ...

A 73-year-old Caucasian man with type 2 diabetes was referred with a 7-month history of an ulcer on his left heel. His left heel had ulcerated on two previous occasions as a result of fissures and using his heel to prop himself up in bed. He had a prior right aboveknee amputation due to trauma. He was known to have peripheral neuropathy but had good pedal pulses. The ulcer was superficial and i...

To cite: Murad A, Fortune A, O’ Keane C, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2016215568 DESCRIPTION A man in his 60s presented with a painful and nonpruritic facial eruption of 1-year duration, which was progressively worsening. He had neither ocular symptoms nor fever. He had been diagnosed with chronic lymphocytic leukaemia (CLL) 15 years prio...

Dear Editor, Marjolin’s ulcer is a rare, well-defined, uncommon, and often aggressive malignant transformation,1 secondary to burn injuries and other inflammatory changes such as venous insufficiency ulcers, pressure ulcers, traumatic wounds, cystostomy sites, scarring from lupus, amputation stumps, chronic lymphedema, chronic pilonidal sinuses, hidradenitis suppurativa, chronic ulcers of lepro...

I tching or pruritus is an unpleasant sensation that evokes the desire or reflex to scratch. Itching in people with diabetes for the most part suggests a skin condition such as psoriasis, eczema, sunburn, athlete’s foot, hidradenitis suppurativa, pruritus vulvae from monilial infections, xerosis and diabetic eczema, necrobiosis diabeticorum, allergies to medications, drug eruptions, and many ot...