BACKGROUND The maternal variables that affect fetal development and correlate with necrotizing enterocolitis (NEC), the most common gastrointestinal emergency in premature infants, are not well defined. We hypothesized that maternal risk factors were the primary determinant of future development of NEC. METHODS Patients with NEC were identified from an established NICU database and were contr...

BACKGROUND Necrotizing Enterocolitis (NEC) is a major source of neonatal morbidity and mortality. There is an ongoing need for a sensitive diagnostic instrument to discriminate NEC from neonatal sepsis. We hypothesized that magnetic nanopartile-based biosensor analysis of gut injury-associated biomarkers would provide such an instrument. STUDY DESIGN We designed a magnetic multiplexed biosens...

It is unclear whether the broad inflammatory response shown in neonatal necrotizing enterocolitis (NEC) is the cause or the effect of tissue injury. Toll-like receptors (TLRs) on intestinal dendritic, mononuclear, and epithelial cells recognize bacterial ligands and damaged tissues, thus activating the inflammatory response. The present study aimed to determine whether active TLR signaling woul...

Necrotizing enterocolitis (NEC) is a common and devastating disease of premature infants. Immaturity of the innate immune system of the gut is central to the pathogenesis of NEC. Recent studies suggest a key role for Paneth cells in this disease. Addressing basic questions on the development and function of immature Paneth cells may shed light on the puzzling pathophysiology of NEC. Current ani...

Minekawa, Ryoko, Takashi Takeda, Masahiro Sakata, Masami Hayashi, Aki Isobe, Toshiya Yamamoto, Keiichi Tasaka, and Yuji Murata. Human breast milk suppresses the transcriptional regulation of IL-1 -induced NFB signaling in human intestinal cells. Am J Physiol Cell Physiol 287: C1404–C1411, 2004. First published June 30, 2004; doi:10.1152/ajpcell.00471.2003.—Neonatal necrotizing enterocolitis (NE...

BACKGROUND Necrotizing Enterocolitis (NEC) affects 5-10% of NICU patients where initially patients may have only nonspecific clinical findings. A noninvasive tool for detection would aid in diagnosis. Increased urinary claudins have been associated with active adult inflammatory bowel disease. METHODS Institutional Review Board approval was obtained. Neonatal intestinal tissue samples were ob...

INTRODUCTION At the Department of Neonatology at Rigshospitalet, Copenhagen, Denmark, decades of extensive use of mother's milk and human donor milk should theoretically limit the incidence of necrotising enterocolitis (NEC) among very low birth weight infants. The aim of this study was to determine our local incidence of NEC from 1996 to 2009. METHODS The data in departmental clinical databa...

Introduction: Necrotizing enterocolitis (NEC) remains a common gastrointestinal disease in preterm infants. Inappropriate bacterial colonization of the gut, together with enteral formula feeding, predispose to NEC in both preterm infants and preterm pigs. Regardless, it remains unclear how and when to manipulate the gut microbiota (e.g. by use of pre-, proor antibiotics) to improve mucosal immu...

This article explores the interaction of verbal and visual art in Virginia Woolf’s fiction, exemplified by her novel, To Lighthouse. The narrative novel not only features scenes painting Ramsays’ portrait, but it unfolds as creative process advances concludes with Lily’s final stroke brush. While words are used to enact creation, serves both a frame basis for verbal. synergistic movement storyt...