OBJECTIVES We explored the prescription of β-blockers with ivabradine in patients with systolic heart failure, focusing on the most frequently coprescribed β-blocker, carvedilol. METHODS We analyzed outcomes in SHIFT patients with systolic heart failure who were prescribed β-blockers (carvedilol, bisoprolol, metoprolol, or nebivolol) with ivabradine or placebo. Analysis was by intention to tr...

While the role of the adrenergic nervous system in the progression of left ventricular failure has been well established, its contribution to the pathogenesis of pulmonary arterial hypertension (PAH) and the resultant right ventricular failure is far less clear. The earliest attempts to treat PAH included drugs that were α-adrenergic agonists such as tolazoline [1] and isoproterenol [2]; unfort...

Nebistar-SA is available for the treatment of stage II hypertension. It contains nebivolol (NV; 5 mg) and amlodipine (AM; 2.5 mg). In the present study, simple, rapid, precise and accurate method for the simultaneous estimation of these drugs have been developed and validated by UV spectrophotometry. The method was validated with respect to its linearity, limit of quantitation (LOQ), limit of d...

Beta blockers are used for the management of arterial hypertension and are gold standard treatment for coronary artery disease and heart failure, medical conditions that affect large numbers of older patients and are associated with very high morbidity and mortality rates. Lifelong therapy in primary and secondary prevention (without and with established cardiovascular disease, respectively) is...

BACKGROUND Many diabetics develop hypertension, and it is a major risk factor for cardiovascular and microvascular complications. OBJECTIVE To review a case study of a patient with poorly controlled hypertension and diabetes. SUMMARY Further assessment of this case study shows that the patient has poorly controlled hypertension, despite multiple medications. The patient also has metabolic s...

The present study was under taken to assess the comparative e f fec t s o f neb ivo lo l wi th p roprano lo l and a teno lo l on psychomotor performances. Thirty healthy volunteers were randomized into three groups with n=10 in each group. Each subject received single dose of one of the three medications (nebivolol 5 mg, atenolol 50 mg and propranolol 40 mg) in morning (9.00 AM). Just before ad...

Since 1992 the mouse has become an excellent model for experimental atherosclerosis research. Until 1992, the diet induced atherosclerosis mouse model has been used effectively, but the lesions tended to be small and were limited to early fatty-streak stage. In 1992 the first line of gene targeted animal models, namely apolipoprotein E (apoE)-single knockout mice was developed. Of the genetical...

Because carvedilol is a unique vasodilating β blocker (BB) exerting antioxidant activity and pleiotropic effects, it was theorized that it may confer more potent beneficial effects on cardiovascular mortality and morbidity in acute myocardial infarction (AMI) and heart failure (HF) settings. A systematic review and meta-analysis was performed of randomized, controlled, direct-comparison trials ...