HYPOTHESIS Despite the success of infrainguinal arterial bypass in diabetic limb and foot salvage, optimism remains guarded because of purported high late mortality and limb loss in patients with diabetes. DESIGN Inception cohort, with minimum 5-year follow-up. SETTING Tertiary referral center. PATIENTS Eight hundred forty-three consecutive patients undergoing lower extremity arterial rec...

Hematological abnormalities associated with the diabetic state include reduced platelet function, enhanced factor activation and hyperfibrinolysis. The present investigation evaluated blood loss and the transfusion requirements in diabetic and non-diabetic patients undergoing extracorporeal circulation and cardiac surgery. A retrospective study of 151 consecutive patients undergoing primary cor...

Abstract Bacterial carbapenem resistance, especially when mediated by transferable carbapenemases, is of important public health concern. An increased number metallo-β-lactamase (MBL)-producing Klebsiella pneumoniae strains isolated in a tertiary hospital Thessaloniki, Greece, called for further genetic investigation. The study included 29 non-repetitive resistant K. isolates phenotypically cha...

The two most common forms of non-dystrophic myotonia (NDM) are congenita (Thomsen disease or Becker-type) and paramyotonia congenita. Symptoms, including muscle stiffness, cramps, transient weakness, can affect a person’s quality life. An unmet need for validated tool to assess symptom severity frequency, as well disability caused by myotonia, led the development Clinical Myotonia Rating Scale ...

The first goal of this article is to analyze the performance of dither modulation (DM) against the composite attacks including valumetric scaling, additive noise and constant change. The analyzes are developed under the assumptions that the host vector and noise vector are mutually independent and both of them have independently and identically distributed components. We derive the general expr...

The emergence and spread of antibiotic-resistant pathogens is a global public health problem. Metallo-β-lactamases (MβLs) such as New Delhi MβL-1 (NDM-1) are principle contributors to the emergence of resistance because of their ability to hydrolyze almost all known β-lactam antibiotics including penicillins, cephalosporins, and carbapenems. A clinical inhibitor of MBLs has not yet been found. ...

In neonatal diabetes mellitus (NDM), a rare genetic disorder, insulin therapy is required but the management is difficult. Frequent blood glucose determinations are necessary in most cases. Microdialysis subcutaneous glucose monitoring (MSGM) is feasible in neonates and has been proposed to reduce painful blood sampling and blood loss. We have applied long-term MSGM to a small-for-date female n...

The Naturalistic Decision Making (NDM) addresses how human decision makers can deal with constraints of time and information. In general, NDM theories are consistent with expert decision making but tend to be very general, referring to broad categories of cognitive processes such as recognition, pattern matching, and mental simulation, without explaining exactly how these processes are performe...

Diabetes is caused by dysfunction to β-cells in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis. Gap junction-mediated electrical coupling between β-cells in the islet plays a major role in coordinating a pulsatile secretory response at elevated glucose and suppressing insulin secretion at basal glucose. Previously, we demonstrated that a critical number of inexci...

BACKGROUND DM remains a risk factor for poor outcome after stent-implantation, but little is known if and how DM affects the vascular response to BVS. AIM The aim of our study was to examine coronary responses to bioresorbable vascular scaffolds (BVS) in swine with and without diabetes mellitus fed a 'fast-food' diet (FF-DM and FF-NDM, respectively) by sequential optical coherence tomography ...