a carbamazepine intoxication with attempt is a relatively common clinical problem that presenting with coma, respiratory depression, arrhythmia, hemodynamic instability and even death. we report a case of severe carbamazepine poisoning that was successfully treated with one session charcoal hemoperfusion. on admission, the patient was comatose and required ventilator support. hemoperfusion with...

herbicide toxicities are considered as an important issue in public health programs of developing countries. this investigation aims at studying epidemiologic toxicities caused by paraquat herbicide and comparing factors influencing these patients’ causality in kermanshah imam khomeini hospital. in a descriptive-survey study, 9 patients poisoned by paraquat herbicide were considered statistical...

The present study describes the cytotoxic, acute toxicity and phytotoxic activities of Callicarpa macrophylla belonging to family Verbanaceae. Brine shrimps cytotoxic bioassay of crude extract of bark of C. macrophylla (CBE) showed 975.22 LD50 value and crude extract of leaves of C. macrophylla (CLE) showed no significant results. However, all the test animals were found absolutely safe in acut...

fumigant toxicity of camphor was studied against the aphid aphis craccivora koch and three associated natural enemies, i.e. coccinella undecimpunctata l., aphelinus albipodus hayat & fatima and aphidius colemani viereck. aphis craccivora was the most tolerant one compared with all tested natural enemies as the recorded lc50 values were 12.71, 6.33, 1.16 and 0.48 mg camphor/liter space for t...

green tea extract has plenty of antioxidant. due to the toxicity of synthetic antioxidants, it is necessary that these antioxidants in products such as donuts be replaced with natural antioxidants. the purpose of this research is to reduce the usage of synthetic antioxidants as it is possible. so the extract was extracted and it was used as a natural antioxidant in the dough of donuts. due to t...

The R964C mutation of human DNA polymerase gamma was recently linked to stavudine (d4T)-mediated mitochondrial toxicity. We utilized pre-steady-state kinetics to determine the effect of this mutation on incorporation of natural substrate dTTP and the active metabolite of d4T (d4TTP). The R964C polymerase gamma holoenzyme demonstrated a 33% decrease in dTTP incorporation efficiency and a threefo...

The data from this study were needed to investigate the aquatic toxicity of the natural compounds azulene and longifolene, which were representatives of nearly 500 compounds of 19 chemical classes tentatively identified in Laurentian Great Lakes fish (Hesselberg and Seelye 1982; Passino and Smith 1987). There are growing concerns over the potential toxic and ecological effects of these hydroand...

The aim of this study was to examine correlation between anti-inflammatory activity and molecular properties of the ten selected natural products in search of a lead compound through Molinspiration, Osiris and PASS cheminformatics software. Ten naturally occurring natural products of diverse chemical classes which seem to be promising and potential candidate for the drug development or identifi...

The combination between anticancer drugs and natural products has great attention aiming at exploiting their efficiency reducing systemic toxicity. Subsequently, the current study was constructed to evaluate potential curative role of crude Sepia ink extract (SIE) Ellagic acid (EA) against cyclophosphamide (CP) Male albino rats were divided into five groups (n = 10). All except group I received...